Background: Women undergoing genetic counseling for hereditary breast cancer often experience a high emotional burden. Distress and stress in the initial phases of genetic counseling can be significant predictors of long-term psychological health, influencing quality of life and well-being.Objectives: This study aimed to evaluate the mediating role of psychophysical stress in the relationship of anxiety and depression with quality of life and well-being in women undergoing genetic counseling for BRCA1/2 mutations.Methods: A sample of 193 women from two genetic counseling clinics was assessed using validated questionnaires measuring the psychological variables under study. Sociodemographic and clinical characteristics were also considered.Results: The results of path analyses indicated a mediating role of psychophysical stress on the relationship between emotional distress and mental quality of life and well-being: higher levels of anxiety and depression were associated with increased psychophysical stress, which, in turn, was linked to a reduced perceived mental quality of life and well-being. Depression was the only significant psychological predictor of physical quality of life.Conclusions: These findings indicate that addressing both anxiety and depression in genetic counseling is crucial for enhancing mental and overall well-being. Interventions should focus on stress management to improve the quality of life, emphasizing depression treatment to enhance physical health outcomes.
背景：接受遗传性乳腺癌遗传咨询的女性常承受较高的情绪负担。遗传咨询初期的痛苦与压力是长期心理健康的重要预测因素，影响生活质量与幸福感。 目的：本研究旨在评估身心压力在焦虑、抑郁与接受BRCA1/2突变遗传咨询女性的生活质量及幸福感关系中的中介作用。 方法：研究选取来自两家遗传咨询诊所的193名女性作为样本，采用经过验证的问卷评估相关心理变量，同时纳入社会人口学及临床特征数据。 结果：路径分析结果显示，身心压力在情绪困扰与心理健康生活质量及幸福感之间起中介作用：较高水平的焦虑和抑郁与身心压力增加相关，而身心压力增加又与感知到的心理健康生活质量及幸福感下降相关。抑郁是影响身体健康生活质量的唯一显著心理预测因子。 结论：研究结果表明，在遗传咨询中同时关注焦虑和抑郁对于提升心理健康及整体幸福感至关重要。干预措施应聚焦于压力管理以改善生活质量，并需特别重视抑郁治疗以促进身体健康。
肿瘤(癌症)患者之家