文章：

包含线场共聚焦光学相干断层扫描（LC-OCT）的无创成像技术在皮肤淋巴瘤诊断中的应用

Non-Invasive Imaging Including Line-Field Confocal Optical Coherence Tomography (LC-OCT) for Diagnosis of Cutaneous Lymphomas

原文发布日期：25 October 2024

DOI: 10.3390/cancers16213608

类型: Article

开放获取: 是

英文摘要：

Background/Objectives:Primary cutaneous lymphomas (PCL) are a heterogeneous group of non-Hodgkin lymphomas arising from malignant T (CTCL) or B (CBCL) cells, often mimicking other skin conditions. Recently, non-invasive diagnostic imaging modalities, including dermoscopy, Reflectance Confocal Microscopy (RCM), and Line-field Optical Coherence Tomography (LC-OCT), have become increasingly important, supporting clinicians in clinical practice. Hence, our study aimed to describe dermoscopic, RCM, and LC-OCT features of PCL and to explore their role in PCL management.Methods: Between December 2022 and January 2024, 40 lesions of 25 patients with PCL were retrospectively analyzed at the Dermatologic Unit of the University of Siena, Italy. Predefined dermoscopic, LC-OCT, and RCM criteria were assessed and their frequencies were calculated.Results:At dermoscopy, CTCL lesions were characterized by pinkish structureless areas (58,6%) and homogeneous distributed dotted vessels (35,7%), whereas 57.1% of CBCL presented with orange-yellow structureless areas. Considering CTCL, lymphocytes in the epidermis, dermal-epidermal junction, and dermis were detected by LC-OCT in 73.1%, 66.7%, and 51.9% and by RCM in 72.2%, 55.6%, and 61.1% of cases, respectively. The detection of lymphocytes was more precise using RCM than LC-OCT in CTCL (p< 0.001). Dermal infiltration of medium-reflective cells was visible in 80% and 40% of CBCL cases by LC-OCT and RCM, respectively.Conclusions: Non-invasive imaging techniques may support clinicians in managing PCL; however, further studies are mandatory in this field.

摘要翻译： 

背景/目的：原发性皮肤淋巴瘤（PCL）是一组异质性的非霍奇金淋巴瘤，起源于恶性T细胞（CTCL）或B细胞（CBCL），其临床表现常与其他皮肤病相似。近年来，包括皮肤镜、反射式共聚焦显微镜（RCM）和线场光学相干断层扫描（LC-OCT）在内的无创诊断成像技术日益重要，为临床医生的诊疗实践提供了支持。因此，本研究旨在描述PCL的皮肤镜、RCM和LC-OCT特征，并探讨这些技术在PCL管理中的作用。 方法：2022年12月至2024年1月期间，在意大利锡耶纳大学皮肤科对25例PCL患者的40处皮损进行了回顾性分析。评估了预定义的皮肤镜、LC-OCT和RCM标准，并计算了其出现频率。 结果：在皮肤镜下，CTCL皮损的特征为粉红色无结构区域（58.6%）和均匀分布的点状血管（35.7%），而57.1%的CBCL皮损表现为橙黄色无结构区域。对于CTCL，LC-OCT分别在73.1%、66.7%和51.9%的病例中检测到表皮、真皮-表皮交界处和真皮内的淋巴细胞，而RCM的检出率分别为72.2%、55.6%和61.1%。在CTCL中，RCM检测淋巴细胞的精确度高于LC-OCT（p < 0.001）。在CBCL病例中，LC-OCT和RCM分别可在80%和40%的病例中观察到中等反射性细胞的真皮浸润。 结论：无创成像技术可为临床医生管理PCL提供支持；然而，该领域仍需进一步研究。

原文链接：

Non-Invasive Imaging Including Line-Field Confocal Optical Coherence Tomography (LC-OCT) for Diagnosis of Cutaneous Lymphomas