Background:Physical activity has been associated with a lower risk of various types of cancer and reduced cancer-specific mortality. Less is known about its impact on pancreatic cancer. The aim of this systematic review and meta-analysis was to summarize evidence on the association between physical activity and pancreatic cancer risk and mortality.Methods: PubMed and Embase were searched until May 2024 for studies examining physical activity in relation to pancreatic cancer incidence and mortality. Summary risk estimates for highest vs. lowest physical activity levels were calculated using a random-effects model. The risk of publication bias was assessed with a funnel plot and Egger’s regression test.Results: A total of seven case–control and eighteen prospective cohort studies were included that investigated the association between physical activity and pancreatic cancer incidence. Our meta-analysis showed a summary estimate of 0.75 (95% CI 0.64–0.88) for case–control studies (I2= 23%,n= 7) and a summary estimate of 0.91 (95% CI 0.86–0.97) for prospective cohort studies (I2= 5%,n= 18). Among the six prospective cohort studies that assessed pancreatic cancer mortality, the summary estimate was 1.03 (95% CI 0.83–1.27), I2= 50%.Conclusions: Higher levels of physical activity were associated with reduced pancreatic cancer risk. Evidence from a limited number of studies suggests that pre-diagnosis physical activity does not affect pancreatic cancer mortality.
背景：体力活动与多种癌症风险降低及癌症特异性死亡率下降相关，但其对胰腺癌的影响尚不明确。本系统综述与荟萃分析旨在总结体力活动与胰腺癌发病风险及死亡率关联的证据。 方法：系统检索截至2024年5月PubMed和Embase数据库中探讨体力活动与胰腺癌发病及死亡率关联的研究。采用随机效应模型计算最高与最低体力活动水平的汇总风险估计值，并通过漏斗图和Egger回归检验评估发表偏倚风险。 结果：共纳入7项病例对照研究和18项前瞻性队列研究探讨体力活动与胰腺癌发病率的关联。荟萃分析显示，病例对照研究的汇总估计值为0.75（95% CI 0.64–0.88，I²=23%，n=7），前瞻性队列研究的汇总估计值为0.91（95% CI 0.86–0.97，I²=5%，n=18）。在评估胰腺癌死亡率的6项前瞻性队列研究中，汇总估计值为1.03（95% CI 0.83–1.27，I²=50%）。 结论：较高水平的体力活动与胰腺癌风险降低相关。有限的研究证据表明，诊断前体力活动对胰腺癌死亡率无显著影响。
肿瘤(癌症)患者之家