Introduction: Low anterior resection syndrome (LARS) can be a debilitating condition that develops after undergoing sphincter-preserving surgery for rectal cancer. Chemotherapy-induced peripheral neuropathy is a common side effect of platinum-based chemotherapy agents used as systemic therapy for rectal cancer treatment. The purpose of this study was to determine the potential relationship between CIPN and LARS. Methods: This was a retrospective review of patients who underwent a low anterior resection for rectal cancer and received systemic therapy contacted at least six months from the most recent surgery. Eligible patients were called and completed the relevant surveys over the phone or email. Results: There was a total of 42 patients who completed the surveys with 33 (79%) having major LARS. Presence of a diverting ileostomy was the only significantly differentcharacteristic in those with major LARS versus those without. CIPN was independently associated with LARS (p= 0.046) on linear regression when controlling for neoadjuvant chemoradiation, diverting ileostomy and tumor distance from the anal verge. Conclusions: Developing severe CIPN is associated with developing LARS. Further studies evaluating the etiology behind this relationship should be conducted.
引言：低位前切除综合征（LARS）是直肠癌患者接受保留括约肌手术后可能出现的严重功能障碍。化疗诱导的周围神经病变（CIPN）是直肠癌系统治疗中铂类化疗药物的常见副作用。本研究旨在探讨CIPN与LARS之间的潜在关联。方法：本研究回顾性分析了接受直肠癌低位前切除手术并接受系统治疗的患者，所有患者在末次手术后至少六个月接受随访。通过电话或邮件对符合条件者进行问卷调查。结果：共42例患者完成调查，其中33例（79%）存在重度LARS。与无重度LARS患者相比，存在转流性回肠造口是唯一具有显著差异的特征。在控制新辅助放化疗、转流性回肠造口及肿瘤距肛缘距离等变量后，线性回归分析显示CIPN与LARS存在独立相关性（p=0.046）。结论：重度CIPN的发生与LARS的发展存在关联，需进一步研究探讨其内在机制。
Association Between Chemotherapy-Induced Peripheral Neuropathy and Low Anterior Resection Syndrome
肿瘤(癌症)患者之家