文章：

肝内胆管癌肿瘤免疫微环境：调控机制、功能及治疗意义

Tumor Immune Microenvironment in Intrahepatic Cholangiocarcinoma: Regulatory Mechanisms, Functions, and Therapeutic Implications

原文发布日期：20 October 2024

DOI: 10.3390/cancers16203542

类型: Article

开放获取: 是

英文摘要：

Treatment options for intrahepatic cholangiocarcinoma (iCCA), a highly malignant tumor with poor prognosis, are limited. Recent developments in immunotherapy and immune checkpoint inhibitors (ICIs) have offered new hope for treating iCCA. However, several issues remain, including the identification of reliable biomarkers of response to ICIs and immune-based combinations. Tumor immune microenvironment (TIME) of these hepatobiliary tumors has been evaluated and is under assessment in this setting in order to boost the efficacy of ICIs and to convert these immunologically “cold” tumors to “hot” tumors. Herein, the review TIME of ICCA and its critical function in immunotherapy. Moreover, this paper also discusses potential avenues for future research, including novel targets for immunotherapy and emerging treatment plans aimed to increase the effectiveness of immunotherapy and survival rates for iCCA patients.

摘要翻译： 

肝内胆管癌（iCCA）是一种高度恶性且预后不良的肿瘤，其治疗选择有限。近年来，免疫疗法及免疫检查点抑制剂（ICIs）的发展为iCCA的治疗带来了新希望。然而，仍存在若干问题亟待解决，包括寻找可靠的ICIs应答生物标志物以及探索基于免疫的联合治疗方案。为提升ICIs疗效，并将这些免疫学上的“冷”肿瘤转化为“热”肿瘤，目前已在评估肝胆肿瘤的肿瘤免疫微环境（TIME），并在此背景下持续深入研究。本文综述了iCCA的TIME特征及其在免疫治疗中的关键作用，同时探讨了未来研究的潜在方向，包括免疫治疗的新靶点及旨在提高iCCA患者免疫治疗效果与生存率的新兴治疗方案。

原文链接：

Tumor Immune Microenvironment in Intrahepatic Cholangiocarcinoma: Regulatory Mechanisms, Functions, and Therapeutic Implications