Introduction:Ganglioneuroma (GN) is a rare, benign tumor of the autonomic nervous system. It is seldom located in the head and neck (HN) region. GN typically presents as a slow-growing, painless mass, often leading to delayed diagnosis.Case report:We report a unique case of laryngeal-originating GN in a 43-year-old female who presented with worsening dysphonia and dyspnea. Imaging revealed a large mass originating from the larynx. Histological examination confirmed the diagnosis. The tumor was surgically excised with preservation of key structures in the neck. At the follow-up, the patient experienced a significant improvement in symptoms.Material and methods:A systematic literature review following PRISMA guidelines was conducted in January 2024 to investigate the common sites of GN in the HN region and the complications associated with its treatment.Results:In a total of 58 articles, we studied 65 patients, mostly under 30 years old. Surgical excision remains the primary treatment, and post-operative complications were mostly neurological.Discussion:GNs are generally slow-growing and asymptomatic, but they can reveal themselves when compressing nearby structures, especially in the HN region. In symptomatic cases or when the tumor exhibits significant growth or hormonal activity, surgical resection is required. The lateral cervical approach is the most common one. The risk of postoperative complications and recurrence underscores the need for careful surgical planning and long-term follow-up.Conclusion:This unique laryngeal GN case highlights the importance of considering GN in the differential diagnosis of HN masses. Further large-scale studies are warranted to establish evidence-based protocols for their management, especially in the HN region.
引言：神经节细胞瘤是一种罕见的自主神经系统良性肿瘤，罕见于头颈部区域。该肿瘤通常表现为生长缓慢的无痛性肿块，常导致诊断延迟。 病例报告：本文报告一例罕见的喉部起源神经节细胞瘤病例。患者为43岁女性，表现为进行性加重的发声障碍和呼吸困难。影像学检查发现喉部起源的巨大肿块，组织学检查确诊为神经节细胞瘤。通过手术切除肿瘤并保留颈部关键结构，术后随访显示患者症状显著改善。 材料与方法：我们于2024年1月遵循PRISMA指南进行了系统性文献综述，旨在探究神经节细胞瘤在头颈部的常见发病部位及其治疗相关并发症。 结果：通过对58篇文献中65例患者的分析发现，患者年龄多在30岁以下。手术切除仍是主要治疗方式，术后并发症以神经功能障碍为主。 讨论：神经节细胞瘤通常生长缓慢且无症状，但当压迫邻近结构（尤其在头颈部）时可出现临床表现。对于有症状、肿瘤显著生长或具有激素活性的病例，需行手术切除。颈侧入路是最常用的手术方式。术后并发症和复发风险提示需要精细的手术规划和长期随访。 结论：本病例提示在头颈部肿块的鉴别诊断中应考虑神经节细胞瘤的可能。未来需要开展大规模研究以建立基于证据的诊疗规范，特别是在头颈部区域。
肿瘤(癌症)患者之家