文章：

治疗人乳头瘤病毒相关恶性肿瘤的潜在治疗靶点

Potential Therapeutic Targets for the Treatment of HPV-Associated Malignancies

原文发布日期：14 October 2024

DOI: 10.3390/cancers16203474

类型: Article

开放获取: 是

英文摘要：

This review article aims to summarize broadly recent developments in the treatment of HPV-associated cancers, including cervical cancer and head and neck squamous cell carcinoma. Relatively new treatments targeting the key HPV E6 and E7 oncoproteins, including gene editing with TALENs and CRISPR/Cas9, are discussed. Given the increased immunogenicity of HPV-related diseases, other therapies such as PRR agonists, adoptive cell transfer, and tumor vaccines are reaching the clinical trial phase. Due to the mechanism, immunogenicity, and reversibility of HPV carcinogenesis, HPV-related cancers present unique targets for current and future therapies.

摘要翻译： 

本综述旨在全面概述人乳头瘤病毒（HPV）相关癌症（包括宫颈癌及头颈部鳞状细胞癌）治疗领域的最新进展。文章重点讨论了针对HPV关键致癌蛋白E6和E7的新型治疗策略，特别是基于TALENs和CRISPR/Cas9系统的基因编辑技术。鉴于HPV相关疾病具有较高的免疫原性，模式识别受体激动剂、过继性细胞免疫疗法及肿瘤疫苗等其他治疗手段已进入临床试验阶段。基于HPV致癌机制的明确性、疾病免疫原性特征及致癌过程的可逆性特点，HPV相关癌症为当前及未来的靶向治疗提供了独特的研究方向。

原文链接：

Potential Therapeutic Targets for the Treatment of HPV-Associated Malignancies