文章：

用于癌症治疗的Mortalin合成与天然抑制剂

Synthetic and Natural Inhibitors of Mortalin for Cancer Therapy

原文发布日期：13 October 2024

DOI: 10.3390/cancers16203470

类型: Article

开放获取: 是

英文摘要：

Upregulation of stress chaperone Mortalin has been closely linked to the malignant transformation of cells, tumorigenesis, the progression of tumors to highly aggressive stages, metastasis, drug resistance, and relapse. Various in vitro and in vivo assays have provided evidence of the critical role of Mortalin upregulation in promoting cancer cell characteristics, including proliferation, migration, invasion, and the inhibition of apoptosis, a consistent feature of most cancers. Given its critical role in several steps in oncogenesis and multi-modes of action, Mortalin presents a promising target for cancer therapy. Consequently, Mortalin inhibitors are emerging as potential anti-cancer drugs. In this review, we discuss various inhibitors of Mortalin (peptides, small RNAs, natural and synthetic compounds, and antibodies), elucidating their anti-cancer potentials.

摘要翻译： 

应激伴侣蛋白Mortalin的上调与细胞恶性转化、肿瘤发生、肿瘤进展至高度侵袭阶段、转移、耐药及复发密切相关。多项体外和体内实验证据表明，Mortalin上调在促进癌细胞特性（包括增殖、迁移、侵袭及抑制凋亡）中发挥关键作用，这些特性是大多数癌症的共有特征。鉴于Mortalin在肿瘤发生多个环节中的关键作用及其多模式作用机制，该蛋白成为极具前景的癌症治疗靶点。因此，Mortalin抑制剂正逐渐显现出作为潜在抗癌药物的价值。本综述系统探讨了各类Mortalin抑制剂（包括多肽、小RNA、天然与合成化合物及抗体），并阐明其抗癌潜力。

原文链接：

Synthetic and Natural Inhibitors of Mortalin for Cancer Therapy