Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues formed by the accumulation of lymphocytes and other components outside lymphoid organs. They have been shown to be widespread in cancers and have predictive effects on prognosis and immunotherapy efficacy; however, there is no standardized measurement guide. This paper provides a reference for future research. Moreover, the induction strategy for the formation mechanism of TLSs is a new direction for future cancer treatment, such as cancer vaccines for microorganisms. The effects of microorganisms on cancer are dual. The role of microorganisms, including bacteria, parasites, viruses, and fungi, in promoting cancer has been widely confirmed. However, the specific mechanism of their tumor suppressor effect, particularly the promotion of TLS formation, is currently unknown. In this review, we summarize the role of TLSs in cancer related to microbial infection and provide new ideas for further understanding their mechanisms of action in cancer.
三级淋巴结构（TLSs）是由淋巴细胞及其他成分在淋巴器官外聚集形成的异位淋巴组织。研究表明其在癌症中广泛存在，并对预后及免疫治疗疗效具有预测作用，但目前尚无标准化的测量指南。本文为后续研究提供参考。此外，针对TLSs形成机制的诱导策略是未来癌症治疗的新方向，例如微生物癌症疫苗。微生物对癌症的影响具有双重性。包括细菌、寄生虫、病毒和真菌在内的微生物在促进癌症发生方面的作用已得到广泛证实，但其抑癌作用的具体机制，特别是促进TLS形成的机制目前尚不明确。本综述总结了TLSs在与微生物感染相关癌症中的作用，为进一步理解其在癌症中的作用机制提供新思路。
Tertiary Lymphoid Structures in Microorganism-Related Cancer
肿瘤(癌症)患者之家