Background: Differences in the incidence of breast cancer subtypes among racial/ethnic groups have been evaluated as a contributing factor in disparities seen in breast cancer prognosis. We evaluated new breast cancer cases in Hawai’i to determine if there were subtype differences according to race/ethnicity that may contribute to known disparities. Methods: We reviewed 4591 cases of women diagnosed with breast cancer from two large tumor registries between 2015 and 2022. We evaluated breast cancer cases according to age at diagnosis, self-reported race, breast cancer subtype (ER, PR, and HER2 receptor status), histology, county, and year. Results: We found both premenopausal and postmenopausal Native Hawaiian women were less likely to be diagnosed with triple-negative breast cancer (OR = 0.26, 95% CI 0.12–0.58p= 0.001; OR = 0.54, 95% CI 0.36, 0.80p= 0.002, respectively). Conclusions: The results of our study support that there are racial/ethnic differences in breast cancer subtypes among our population, which may contribute to differences in outcomes. Further evaluation of clinical and pathological features in each breast cancer subtype may help improve the understanding of outcome disparities seen among different racial/ethnic groups.
背景：乳腺癌亚型在不同种族/族裔群体中的发病率差异已被视为影响乳腺癌预后差异的重要因素。本研究通过分析夏威夷地区新发乳腺癌病例，旨在探究不同种族/族裔群体在乳腺癌亚型分布上是否存在差异，从而解释已知的预后差异现象。方法：我们回顾性分析了2015年至2022年间来自两个大型肿瘤登记处的4591例女性乳腺癌确诊病例，根据诊断年龄、自我报告的种族、乳腺癌亚型（ER、PR和HER2受体状态）、组织学类型、所在县及诊断年份进行分层评估。结果：研究发现，无论是绝经前还是绝经后的夏威夷原住民女性，其罹患三阴性乳腺癌的风险均显著较低（绝经前：OR=0.26，95% CI 0.12–0.58，p=0.001；绝经后：OR=0.54，95% CI 0.36–0.80，p=0.002）。结论：本研究证实了夏威夷地区不同种族/族裔群体在乳腺癌亚型分布上存在差异，这可能是导致预后差异的原因之一。未来通过对各乳腺癌亚型的临床与病理特征进行深入分析，将有助于进一步理解不同种族/族裔群体间乳腺癌结局差异的形成机制。
Differences in Breast Cancer Subtypes among Racial/Ethnic Groups
肿瘤(癌症)患者之家