文章：

乳腺癌中MUC1家族唾液酸跨膜黏蛋白（CA 15-3、CA 27.29、MCA）的研究：人表皮生长因子受体2（HER2）的影响

Salivary Transmembrane Mucins of the MUC1 Family (CA 15-3, CA 27.29, MCA) in Breast Cancer: The Effect of Human Epidermal Growth Factor Receptor 2 (HER2)

原文发布日期：12 October 2024

DOI: 10.3390/cancers16203461

类型: Article

开放获取: 是

英文摘要：

The MUC1 family of transmembrane glycoproteins (CA 15-3, CA 27.29, MCA) is aberrantly expressed among patients with breast cancer.Objectives: to measure the level of degradation products of MUC1, including CA 15-3, CA 27.29, and MCA, in the saliva of breast cancer patients and to describe the biochemical processes that influence their expression and the regulation of their biological functions.Methods: The case–control study included three groups (breast cancer, fibroadenomas, and healthy controls). All study participants provided saliva samples strictly before starting treatment. The levels of MUC1, including CA 15-3, CA 27.29, and MCA, free progesterone and estradiol, cytokines (MCP-1, VEGF, TNF-α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-18), and amino acids (Asp, Gln, Gly, His, Leu + Ile, Orn, Phe, Pro, Tyr) were determined.Results: It was shown that the levels of the MUC1 family in the saliva of patients with HER2-positive breast cancer were significantly lower compared to the control group. The level of pro-inflammatory cytokines and the level of free estradiol affected the expression of MUC1. We obtained a reliable relationship between the aggressive nature of tumor growth, an increased level of pro-inflammatory cytokines, a low level of free estradiol, and the suppressed expression of salivary MUC1.Conclusions: Among patients with aggressive breast cancer, a high level of pro-inflammatory cytokines, and a low level of free estradiol, there was an inhibition of the expression of pathologically unchanged glycoprotein MUC1 in saliva.

摘要翻译： 

跨膜糖蛋白MUC1家族（CA 15-3、CA 27.29、MCA）在乳腺癌患者中呈现异常表达。研究目的：测定乳腺癌患者唾液中MUC1降解产物（包括CA 15-3、CA 27.29和MCA）的水平，并阐述影响其表达及生物学功能调控的生化过程。研究方法：本病例对照研究纳入三组人群（乳腺癌组、纤维腺瘤组及健康对照组）。所有研究对象均在开始治疗前严格采集唾液样本。检测指标包括MUC1（含CA 15-3、CA 27.29和MCA）、游离孕酮与雌二醇、细胞因子（MCP-1、VEGF、TNF-α、IL-1β、IL-2、IL-4、IL-6、IL-8、IL-10、IL-18）及氨基酸（天冬氨酸、谷氨酰胺、甘氨酸、组氨酸、亮氨酸+异亮氨酸、鸟氨酸、苯丙氨酸、脯氨酸、酪氨酸）。研究结果：数据显示HER2阳性乳腺癌患者唾液中的MUC1家族水平显著低于对照组。促炎细胞因子水平与游离雌二醇水平共同影响MUC1的表达。研究发现肿瘤侵袭性生长特征、促炎细胞因子水平升高、游离雌二醇水平降低与唾液MUC1表达抑制之间存在可靠关联。研究结论：在具有侵袭性乳腺癌特征、高促炎细胞因子水平及低游离雌二醇水平的患者中，唾液中病理学未改变的糖蛋白MUC1的表达受到抑制。

原文链接：

Salivary Transmembrane Mucins of the MUC1 Family (CA 15-3, CA 27.29, MCA) in Breast Cancer: The Effect of Human Epidermal Growth Factor Receptor 2 (HER2)