文章：

肿瘤相关巨噬细胞作为肿瘤微环境中的主要免疫抑制细胞

Tumor-Associated Macrophages as Major Immunosuppressive Cells in the Tumor Microenvironment

原文发布日期：8 October 2024

DOI: 10.3390/cancers16193410

类型: Article

开放获取: 是

英文摘要：

Within the tumor microenvironment, myeloid cells constitute a dynamic immune population characterized by a heterogeneous phenotype and diverse functional activities. In this review, we consider recent literature shedding light on the increasingly complex biology of M2-like immunosuppressive tumor-associated macrophages (TAMs), including their contribution to tumor cell invasion and metastasis, stromal remodeling (fibrosis and matrix degradation), and immune suppressive functions, in the tumor microenvironment (TME). This review also delves into the intricate signaling mechanisms underlying the polarization of diverse macrophage phenotypes, and their plasticity. We also review the development of promising therapeutic approaches to target these populations in cancers. The expanding knowledge of distinct subsets of immunosuppressive TAMs, and their contributions to tumorigenesis and metastasis, has sparked significant interest among researchers regarding the therapeutic potential of TAM depletion or phenotypic modulation.

摘要翻译： 

在肿瘤微环境中，髓系细胞构成了一种动态的免疫群体，其特征表现为异质性的表型和多样化的功能活性。本综述探讨了近期文献中关于M2样免疫抑制性肿瘤相关巨噬细胞日益复杂的生物学特性，包括其在肿瘤微环境中对肿瘤细胞侵袭与转移、基质重塑（纤维化与基质降解）以及免疫抑制功能的贡献。本文还深入探讨了不同巨噬细胞表型极化及其可塑性的复杂信号机制。同时，我们综述了针对这些细胞群在癌症治疗中具有前景的治疗策略的发展。对免疫抑制性TAMs不同亚群的深入认识及其在肿瘤发生和转移中的作用，已激发研究者们对TAMs清除或表型调控治疗潜力的极大兴趣。

原文链接：

Tumor-Associated Macrophages as Major Immunosuppressive Cells in the Tumor Microenvironment