文章：

室管膜下巨细胞星形细胞瘤：分子景观与治疗进展

Subependymal Giant Cell Astrocytoma: The Molecular Landscape and Treatment Advances

原文发布日期：7 October 2024

DOI: 10.3390/cancers16193406

类型: Article

开放获取: 是

英文摘要：

Subependymal giant cell astrocytoma (SEGA) is most often found in patients with TSC (Tuberous Sclerosis Complex). Although it has been classified as a benign tumor, it may create a serious medical problem leading to grave consequences, including young patient demise. Surgery and chemotherapy belong to the gold standard of treatment. A broader pharmacological approach involves the ever-growing number of rapalogs and ATP-competitive inhibitors, as well as compounds targeting other kinases, such as dual PI3K/mTOR inhibitors and CK2 kinase inhibitors. Novel approaches may utilize noncoding RNA-based therapeutics and are extensively investigated to this end. The purpose of our review was to characterize SEGA and discuss the latest trends in the diagnosis and therapy of this disease.

摘要翻译： 

室管膜下巨细胞星形细胞瘤（SEGA）最常见于结节性硬化症（TSC）患者。尽管该肿瘤被归类为良性，但仍可能引发严重的临床问题，甚至导致包括年轻患者死亡在内的严重后果。手术与化疗属于标准治疗方案。更广泛的药理学方法涉及不断增加的雷帕霉素类似物和ATP竞争性抑制剂，以及针对其他激酶的化合物，例如双重PI3K/mTOR抑制剂和CK2激酶抑制剂。新兴疗法可能采用基于非编码RNA的治疗策略，目前正为此开展广泛研究。本综述旨在阐述SEGA的病理特征，并探讨该疾病诊断与治疗的最新进展。

原文链接：

Subependymal Giant Cell Astrocytoma: The Molecular Landscape and Treatment Advances