文章：

三种不同运动方式对治疗后乳腺癌幸存者六个月压力水平的影响

Impact of Six Months of Three Different Modalities of Exercise on Stress in Post-Treatment Breast Cancer Survivors

原文发布日期：4 October 2024

DOI: 10.3390/cancers16193398

类型: Article

开放获取: 是

英文摘要：

Background/Objectives: Extensive evidence suggests that exercise is physically and mentally beneficial for cancer survivors. This study reports on changes in self-reported stress, physiological biomarkers for stress (salivary cortisol), and HR-QOL constructs for fifty breast cancer survivors participating in one of three different exercise programs over 6 months. Methods: Fifty post-treatment breast cancer survivors were randomized to either therapeutic yoga-based exercise (YE), comprehensive exercise (CE) (aerobic, resistance, flexibility), or choosing (C) their own exercise activities. Participants completed the Perceived Stress Scale (PSS), Medical Outcomes Short-Form 36®(SF-36), and the Pittsburgh Sleep Quality Index (PSQI). Five samples of salivary cortisol were collected on two consecutive days. The 10 samples were used to calculate the diurnal rhythm slope. Outcome measures were repeated after six months. Results: All groups improved in HR-QOL measures of PSS; PSQI sleep quality components of latency and daytime functioning; and five of the ten SF-36 scales (Mental Component Scale, Social Functioning subscale, Mental Health subscale, Physical Component Scale, Physical Functioning subscale). Although the CE group observed the most favorable change in cortisol (−0.183), where cortisol slope changes approached significance (p= 0.057), but no significant decrease in cortisol between groups were noted. Conclusions: Our results suggest that it is the engagement of, rather than the specific type of exercise, which is associated with improved HR-QOL. However, longer-term studies with better adherence monitoring and larger sample sizes are needed to better determine clinical impact.

摘要翻译： 

背景/目的：大量证据表明运动对癌症幸存者具有身心双重益处。本研究报告了50名乳腺癌幸存者在参与三种不同运动项目6个月期间，自我报告压力、压力生理生物标志物（唾液皮质醇）及健康相关生活质量指标的变化情况。方法：50名已完成治疗的乳腺癌幸存者被随机分配至治疗性瑜伽运动组、综合运动组（包含有氧、抗阻及柔韧性训练）或自主选择运动组。参与者完成感知压力量表、医疗结局研究简表36项及匹兹堡睡眠质量指数评估。连续两天采集五次唾液皮质醇样本，共10个样本用于计算昼夜节律斜率。所有结局指标在6个月后重复测量。结果：所有组别在健康相关生活质量指标上均呈现改善趋势，包括感知压力量表得分；睡眠质量指数中的入睡潜伏期和日间功能维度；以及简表36项中的五个分量表（心理成分量表、社会功能子量表、心理健康子量表、身体成分量表、身体功能子量表）。尽管综合运动组观察到最显著的皮质醇变化（-0.183），其皮质醇斜率变化接近统计学意义（p=0.057），但组间皮质醇下降未达显著差异。结论：研究结果表明，健康相关生活质量的改善与运动参与度相关，而非特定运动类型。然而，需要开展更长期、具有更好依从性监测及更大样本量的研究以更准确评估临床影响。

原文链接：

Impact of Six Months of Three Different Modalities of Exercise on Stress in Post-Treatment Breast Cancer Survivors