Background/Objectives:This study aims to investigate differences in cancer diagnosis based on absolute case numbers and age-standardized incidence rate ratios (IRRs) in the pre-Coronavirus disease 2019 (COVID-19) years (2018/19) and the first two years of the COVID-19 pandemic (2020, 2021) in two Swiss cantons.Methods: Data of the Swiss cantonal cancer registry of the cantons of Zurich (ZH) and Zug (ZG) were used to descriptively investigate differences in annual and monthly absolute numbers regarding all-cancer and the five most common cancer types. Directly age-standardized monthly incidence rates (IRs) were calculated. Multivariate Quasipoisson regression models were fitted to determine the IRRs with 95% confidence intervals (95% CI).Results: Annual absolute numbers of all investigated cancers were similar in 2018/19, 2020, and 2021, except for prostate cancer (increase of 20.8% in 2021 compared to 2018/19). In 2020, there were generally more cancer diagnoses in January and February followed by a decrease in April and May. Compared to the pre-COVID-19 period, lower IRs were observed in 2020 for all-cancer (IRR = 0.96 [95% CI 0.96, 0.97]) and female breast cancer (0.92 [0.89, 0.96]), whereas higher IRs were observed in 2021 for all-cancer (1.02 [1.02, 1.02]) and prostate cancer (1.23 [1.18, 1.28]).Conclusions: Cancer detection and diagnoses decreased during the first year of the pandemic, especially during the most stringent lockdown phase in April. The findings of this study may inform the decisions of policymakers and public health system during future pandemics.
背景/目的：本研究旨在调查瑞士两个州（苏黎世州和楚格州）在2019冠状病毒病（COVID-19）疫情前年份（2018/19年）与疫情初期两年（2020年、2021年）期间，基于绝对病例数和年龄标准化发病率比（IRR）的癌症诊断差异。方法：利用苏黎世州和楚格州瑞士州级癌症登记数据，描述性分析所有癌症及五种最常见癌症类型的年度和月度绝对病例数差异。计算直接年龄标准化的月度发病率（IR），并拟合多元准泊松回归模型以确定具有95%置信区间（95% CI）的发病率比。结果：除前列腺癌（2021年较2018/19年增长20.8%）外，所有研究癌症的年度绝对病例数在2018/19年、2020年及2021年间基本持平。2020年1-2月癌症诊断数普遍较高，4-5月出现下降。与疫情前时期相比，2020年所有癌症（IRR=0.96 [95% CI 0.96, 0.97]）和女性乳腺癌（0.92 [0.89, 0.96]）的发病率较低；而2021年所有癌症（1.02 [1.02, 1.02]）和前列腺癌（1.23 [1.18, 1.28]）的发病率较高。结论：疫情首年（特别是4月最严格封锁阶段）癌症检出与诊断数量下降。本研究结果可为未来大流行期间政策制定者与公共卫生系统的决策提供参考。
肿瘤(癌症)患者之家