文章：

就业状况、伴侣关系、癌症类型及手术治疗对接受放射治疗的头颈癌幸存者健康相关生活质量的影响

Impacts of Employment Status, Partnership, Cancer Type, and Surgical Treatment on Health-Related Quality of Life in Irradiated Head and Neck Cancer Survivors

原文发布日期：1 October 2024

DOI: 10.3390/cancers16193366

类型: Article

开放获取: 是

英文摘要：

Objectives: This study aimed to examine the relationship between health-related quality of life (HRQoL) and sociodemographic and clinical variables in survivors of head and neck cancer (HNC) treated with radiotherapy, with or without surgery.Materials and Methods: HRQoL was measured using the functional assessment of cancer therapy—head and neck (FACT-H&N) in a cross-sectional survey involving 150 patients. Of these, 60 had nasopharyngeal cancer (NPC), treated exclusively with radiotherapy, while 90 had oral cavity squamous cell cancer (OSCC), undergoing radical surgery followed by adjuvant radiotherapy. Key variables included cancer type, age, gender, partnership status, education, and employment, with additional clinical variables assessed in patients with OSCC. Statistical analyses included multiple regression, ANOVA, and t-tests to explore relationships between variables and HRQoL.Results: Cancer type, surgical treatment, and employment status emerged as significant independent predictors of HRQoL in HNC patients. Patients with NPC reported better HRQoL on three FACT-H&N subscales—social/family well-being, functional well-being, and additional concerns—compared to patients with OSCC. Unemployed individuals exhibited lower HRQoL on four subscales. In patients with OSCC, partnership status and segmental mandibulectomy were found to predict HRQoL independently.Conclusions: This study concludes that cancer type, surgical intervention, and employment status notably influence HRQoL among HNC patients undergoing radiotherapy. In addition, partnership status is a key factor affecting HRQoL in patients with OSCC.

摘要翻译： 

目的：本研究旨在探讨接受放疗（伴或不伴手术）的头颈癌（HNC）幸存者中，健康相关生活质量（HRQoL）与社会人口学及临床变量之间的关系。 材料与方法：通过横断面调查，使用癌症治疗功能评估量表-头颈版（FACT-H&N）对150例患者进行HRQoL评估。其中60例为鼻咽癌（NPC）患者，仅接受放疗；90例为口腔鳞状细胞癌（OSCC）患者，接受根治性手术及辅助放疗。关键变量包括癌症类型、年龄、性别、伴侣状况、教育程度和就业情况，OSCC患者还评估了其他临床变量。采用多元回归、方差分析和t检验等统计方法分析变量与HRQoL的关系。 结果：癌症类型、手术治疗和就业状况是HNC患者HRQoL的显著独立预测因素。与OSCC患者相比，NPC患者在FACT-H&N量表的三个子维度（社会/家庭幸福感、功能幸福感及附加关注）上表现出更好的HRQoL。失业者在四个子维度上HRQoL较低。在OSCC患者中，伴侣状况和下颌骨节段性切除术被确定为HRQoL的独立预测因素。 结论：本研究得出结论，在接受放疗的HNC患者中，癌症类型、手术干预和就业状况显著影响HRQoL。此外，伴侣状况是影响OSCC患者HRQoL的关键因素。

原文链接：

Impacts of Employment Status, Partnership, Cancer Type, and Surgical Treatment on Health-Related Quality of Life in Irradiated Head and Neck Cancer Survivors