The optimal management of bone tumors requires a multidisciplinary strategy to guarantee high-quality care. At specialized centers, the medical team responsible for managing patients with bone cancer comprises oncologists, surgeons, radiologists, pathologists, and rehabilitation specialists. The goal of treatment is to achieve long-term survival with minimal disability and pain. Postoperative rehabilitation is a fundamental therapeutic approach to enhance functionality and sustain the utmost quality of life following a limb-sparing surgery. Currently, megaprostheses are used for reconstructing bone defects after tumor resection, but in the literature, only a few studies have investigated rehabilitation outcomes in terms of functionality and impact on daily activities. This narrative review explores the functional and quality of life outcomes after the implantation of MUTARS®prostheses in patients with lower extremity bone tumors. A comprehensive search was conducted on PubMed and Scopus using the following MESH terms: “MUTARS”, “Megaprosthesis”, “bone”, “tumors”, “metastasis”, “lower limb”, “rehabilitation”, “outcome”, and “quality of life”, and 10 studies were included. The most frequent oncological pathology was found to be primitive bone tumors treated with modular prostheses. The outcome measures used were the Henderson et al. classification, Harris Hip Scale, Musculoskeletal Tumor Society score, Visual Analog Scale, Range Of Motion, Karnofsky Performance Scale, and quality of life questionnaire. MUTARS®is a well-established treatment option after bone tumor resection, although it involves extensive and complex post-resection reconstruction that exposes joints and tissues to substantial mechanical stress. Proper rehabilitation after MUTARS®surgery is a fundamental therapeutic step, although there is still insufficient evidence in the literature focusing on functional and rehabilitative outcomes. Therefore, more studies and guidelines are needed to define standardized rehabilitation protocols for clinical practice after orthopedic oncologic surgery.
骨肿瘤的最佳管理需要多学科策略以确保高质量的医疗照护。在专科中心，负责骨癌患者管理的医疗团队包括肿瘤科医师、外科医师、放射科医师、病理科医师及康复专家。治疗目标在于实现长期生存的同时，最大限度减少功能障碍与疼痛。术后康复是保肢手术后提升功能、维持最佳生活质量的基础治疗手段。目前，巨型假体被广泛应用于肿瘤切除后骨缺损的重建，但文献中仅有少数研究从功能状态及日常生活影响角度探讨康复效果。本文通过叙述性综述，探讨下肢骨肿瘤患者植入MUTARS®假体后的功能与生活质量结局。研究基于PubMed和Scopus数据库，采用以下医学主题词进行系统检索：“MUTARS”“巨型假体”“骨”“肿瘤”“转移”“下肢”“康复”“结局”及“生活质量”，最终纳入10项研究。结果显示最常见的肿瘤病理类型为采用模块化假体治疗的原发性骨肿瘤。使用的结局评估工具包括Henderson分类法、Harris髋关节评分、肌肉骨骼肿瘤协会评分、视觉模拟评分、关节活动度、卡氏功能状态评分及生活质量问卷。MUTARS®作为骨肿瘤切除后成熟的治疗方案，虽能实现广泛而复杂的切除后重建，但会使关节和组织承受显著的机械应力。规范的MUTARS®术后康复是至关重要的治疗环节，然而目前文献中针对功能与康复结局的研究证据仍显不足。因此，需要更多研究及指南来制定骨科肿瘤手术后临床实践的标准化康复方案。
肿瘤(癌症)患者之家