Background/Objectives: Dysfunctions of metabolic syndrome (MetS) have been identified as a significant risk factor for colorectal cancer (CRC). However, current colon cancer guidelines do not classify patients with MetS as high risk, thereby leaving these individuals vulnerable. Consequently, we explored the relationship between MetS, its individual components, and the development of CRC in a cohort of patients with MetS to assess the necessity for CRC screening in these individuals.Methods: This study included patients ages 18 and older that received a service from the Marshall-Health (MH) practice plan, Cabell-Huntington Hospital (CHH), MU/JCESOM’s Edwards Comprehensive Cancer Center (ECCC), or the University of Kentucky HealthCare (UKHC) system between 2010 and 2018. We implemented log-binomial regression models to assess the individual and collective effects of MetS components after adjusting other CRC risk factors.Results: Given that CRC prevalence increases in the older population (aged 65 years and above), and that multiple components of MetS are observed within the same population, we analyzed the concurrent impact of all MetS components on CRC. Log-binomial regression models were implemented to assess the risk of CRC due to MetS components after adjusting other risk factors.Conclusions: We identified specific components that markedly increased CRC risk, suggesting that individuals with these components should be prioritized for early screening. These findings could significantly influence early CRC screening protocols, with the ultimate aim to reduce mortality associated with the disease.
背景/目的：代谢综合征（MetS）的功能障碍已被确定为结直肠癌（CRC）的重要风险因素。然而，现行结肠癌指南并未将MetS患者归类为高风险人群，导致这些个体处于易感状态。因此，我们在一组MetS患者中探讨了MetS及其各组分与CRC发生之间的关系，以评估这些个体进行CRC筛查的必要性。 方法：本研究纳入了2010年至2018年间在Marshall-Health（MH）实践计划、Cabell-Huntington医院（CHH）、MU/JCESOM的Edwards综合癌症中心（ECCC）或肯塔基大学医疗系统（UKHC）接受服务的18岁及以上患者。在调整其他CRC风险因素后，我们采用对数二项回归模型评估了MetS各组分单独及共同的影响。 结果：鉴于CRC患病率在老年人群（65岁及以上）中增加，且同一人群中观察到MetS的多个组分，我们分析了所有MetS组分对CRC的协同影响。在调整其他风险因素后，采用对数二项回归模型评估了MetS组分导致的CRC风险。 结论：我们识别出显著增加CRC风险的特定组分，表明具有这些组分的个体应优先进行早期筛查。这些发现可能对早期CRC筛查方案产生重要影响，最终目标是降低与该疾病相关的死亡率。
Risk of Colorectal Cancer among Patients with One or Multiple Metabolic Syndrome Components
肿瘤(癌症)患者之家