文章：

放射性引导手术在小而难以定位的复发MIBG阳性高危神经母细胞瘤病灶中的应用

Use of Radioguided Surgery for Small and Difficult-to-Locate Relapsed MIBG (+) High-Risk Neuroblastoma Lesions

原文发布日期：30 September 2024

DOI: 10.3390/cancers16193348

类型: Article

开放获取: 是

英文摘要：

Introduction: High-risk neuroblastoma, particularly in the relapse/refractory (R/R) setting, poses unique challenges to obtaining the representative-quality tissue that is mostly required for molecular analysis. This study explores the use of 123I-MIBG radioguided surgery to access complex locations of MIBG-positive neuroblastoma as a tool to overcome the difficulties associated with repeated surgeries in these patients. Methods: This study is a retrospective review of all patients with R/R neuroblastoma and MIBG-uptaking lesions who underwent radioguided surgery between February 2020 and 2023 at SJD Barcelona Children’s Hospital. The Europrobe 3.2 gamma probe was used to identify neuroblastoma tissue in the operating room. Results: Ten patients were identified. Radioguided surgery was useful in all patients. One patient with previous multiple operations developed an entero-cutaneous fistula with posterior full recovery. Mean surgical time was 111.7 min. The gamma probe identified 100% of neuroblastoma lesions which were all completely removed (123I-MIBG-SPECT/CT negative post-surgery). Pathology and molecular studies could be successfully performed in all samples. Conclusions: 123I-MIBG radioguided surgery proved effective in obtaining viable tissue from difficult-to-access sites in high-risk relapsed neuroblastoma.

摘要翻译： 

引言：高危神经母细胞瘤，尤其是在复发/难治性（R/R）状态下，获取分子分析通常所需的代表性质量组织面临独特挑战。本研究探讨利用¹²³I-MIBG放射引导手术定位MIBG阳性神经母细胞瘤复杂病灶，以克服此类患者重复手术的困难。方法：本研究回顾性分析了2020年2月至2023年间在巴塞罗那圣琼德杜儿童医院接受放射引导手术的所有R/R神经母细胞瘤伴MIBG摄取病灶患者。术中使用Europrobe 3.2伽马探针识别神经母细胞瘤组织。结果：共纳入10例患者。放射引导手术在所有病例中均发挥效用。1例既往多次手术患者出现肠皮瘘，后完全康复。平均手术时间为111.7分钟。伽马探针识别出100%的神经母细胞瘤病灶并实现完全切除（术后¹²³I-MIBG-SPECT/CT呈阴性）。所有样本均成功完成病理学及分子学研究。结论：¹²³I-MIBG放射引导手术被证实能有效从高危复发神经母细胞瘤难以触及部位获取活性组织。

原文链接：

Use of Radioguided Surgery for Small and Difficult-to-Locate Relapsed MIBG (+) High-Risk Neuroblastoma Lesions