The past several years have provided a more profound understanding of the role of microbial species in the lung. The respiratory tract is a delicate ecosystem of bacteria, fungi, parasites, and viruses. Detecting microbial DNA, pathogen-associated molecular patterns (PAMPs), and metabolites in sputum is poised to revolutionize the early diagnosis of lung cancer. The longitudinal monitoring of the lung microbiome holds the potential to predict treatment response and side effects, enabling more personalized and effective treatment options. However, most studies into the lung microbiota have been observational and have not adequately considered the impact of dietary intake and air pollutants. This gap makes it challenging to establish a direct causal relationship between environmental exposure, changes in the composition of the microbiota, lung carcinogenesis, and tumor progression. A holistic understanding of the lung microbiota that considers both diet and air pollutants may pave the way to improved prevention and management strategies for lung cancer.
过去几年，人们对微生物在肺部的作用有了更深入的理解。呼吸道是一个由细菌、真菌、寄生虫和病毒构成的微妙生态系统。通过检测痰液中的微生物DNA、病原相关分子模式（PAMPs）及代谢产物，有望为肺癌的早期诊断带来革命性突破。对肺部微生物组的纵向监测，则可能预测治疗反应及副作用，从而推动更个性化、更有效的治疗方案。然而，目前大多数关于肺部微生物群的研究仍停留在观察层面，未能充分考虑饮食摄入和空气污染物的影响。这一空白使得建立环境暴露、微生物群组成变化、肺癌发生及肿瘤进展之间的直接因果关系面临挑战。若能结合饮食与空气污染物因素，全面理解肺部微生物群，或将为改善肺癌的预防和管理策略开辟新途径。
Impact of the Lung Microbiota on Development and Progression of Lung Cancer
肿瘤(癌症)患者之家