This systematic review aims to explore the diagnostic criteria, epidemiology, etiology, and prognosis of Human Papillomavirus (HPV) infection in lung cancer. This PRISMA-guided review searched the PubMed®and EmbaseTMdatabases for “lung cancer AND HPV” on 10 June 2023, filtering human subject papers. A total of 97 studies encompassing 9098 patients worldwide, revealing varied HPV infection rates in lung cancer, ranging from 0% to 69%, were analyzed. While HPV16/18 was predominant in some regions, its association with lung cancer remained inconclusive due to conflicting findings. Studies from Asia reported lower HPV infection rates compared to Western populations. Some studies suggested a limited role of HPV in lung carcinogenesis, particularly in non-smokers. However, intriguing associations were noted, including HPV’s potential role in lung adenocarcinoma and squamous cell carcinoma. Discrepancies in HPV detection methods and sample sources highlight the need for further research with standardized methodologies to elucidate HPV’s role in lung carcinogenesis and its clinical implications. Overall, this systematic review offers insights into HPV’s role in lung cancer epidemiology and clinical characteristics. Despite inconclusive evidence, intriguing associations between HPV and lung adenocarcinoma and squamous cell carcinoma have emerged. Further research with standardized methodologies and larger cohorts is needed for clarity.
本系统综述旨在探讨人乳头瘤病毒（HPV）感染在肺癌中的诊断标准、流行病学特征、病因学机制及预后影响。本次遵循PRISMA指南的综述于2023年6月10日检索PubMed®和EmbaseTM数据库，以"肺癌与HPV"为关键词筛选人体研究文献。共纳入97项涵盖全球9098例患者的研究，分析显示肺癌组织中HPV感染率存在显著地域差异（0%-69%）。虽然HPV16/18型在某些区域占主导地位，但由于研究结果存在矛盾，其与肺癌的关联性尚未明确。亚洲地区研究报告的HPV感染率普遍低于西方人群。部分研究表明HPV在肺癌发生中的作用有限，尤其在非吸烟群体中。然而研究也发现值得关注的关联性，包括HPV在肺腺癌和鳞状细胞癌中的潜在作用。HPV检测方法与样本来源的差异性凸显了采用标准化方法进行深入研究的必要性，以阐明HPV在肺癌发生中的作用机制及其临床意义。总体而言，本系统综述为理解HPV在肺癌流行病学及临床特征中的作用提供了新视角。尽管现有证据尚未形成定论，但HPV与肺腺癌及鳞状细胞癌之间的潜在关联已初现端倪。未来需通过标准化研究方法扩大样本规模，以进一步明确其作用机制。
肿瘤(癌症)患者之家