Introduction: Racial disparities in gastric cancer outcomes, including stage at diagnosis and overall survival, continue to affect Hispanic and non-Hispanic populations. This study aims to evaluate these disparities across different racial groups. Patients and methods: We conducted a retrospective cohort study using SEER data from 2018 to 2021, including 18,984 patients diagnosed with gastric cancer. Patients were selected based on ICD-O-3 codes for “stomach” with malignant behavior. Using ordered logistic regression, the association between race and stage at diagnosis was analyzed, while Cox proportional hazards models were used to assess OS and CSS. Results: Hispanic patients were significantly more likely to be diagnosed at a later stage compared to non-Hispanic patients (OR: 1.19; 95% CI: 1.10–1.28). Both Hispanic and Black patients had worse OS compared to Non-Hispanic Whites (HR 1.10 CI 1.03–1.17,p= 0.003 and HR 1.13 CI 1.04–1.22,p= 0.002, respectively) as well as CSS. Conclusions: Hispanic patients are more likely to be diagnosed with advanced-stage gastric cancer and have poorer survival outcomes compared to non-Hispanic Whites. These disparities may be linked to differences in healthcare access, insurance, language barriers, and preventive care utilization.
引言：胃癌预后（包括诊断分期和总生存期）的种族差异持续影响西班牙裔与非西班牙裔人群。本研究旨在评估不同种族群体间的此类差异。患者与方法：我们利用2018年至2021年的SEER数据库开展回顾性队列研究，共纳入18,984例胃癌确诊患者。病例筛选基于ICD-O-3中具有恶性行为的"胃"肿瘤编码。采用有序逻辑回归分析种族与诊断分期的关联性，同时使用Cox比例风险模型评估总生存期和癌症特异性生存期。结果：与非西班牙裔患者相比，西班牙裔患者在诊断时处于更晚期的可能性显著更高（OR: 1.19；95% CI: 1.10–1.28）。与非西班牙裔白人相比，西班牙裔和黑人患者的总生存期（HR 1.10 CI 1.03–1.17,p=0.003；HR 1.13 CI 1.04–1.22,p=0.002）及癌症特异性生存期均更差。结论：相较于非西班牙裔白人，西班牙裔患者更可能被诊断为晚期胃癌且生存结局更差。这些差异可能与医疗可及性、保险覆盖、语言障碍及预防性医疗服务利用度的差异相关。
Disparities in Stage at Diagnosis among Hispanic Patients with Gastric Cancer in the United States
肿瘤(癌症)患者之家