Early detection and surgical excision of tumors have helped improve the survival rate of patients with breast cancer. However, patients with metastatic cancer typically have a poor prognosis. In this study, we propose that ANKRD1 promotes metastasis of breast cancer. ANKRD1 was found to be highly expressed in the MDA-MB-231 and MDA-LM-2 highly metastatic breast cancer cell lines compared to the non-metastatic breast cancer cell lines (MCF-7, ZR-75-30, T47D) and normal breast cancer cells (MCF-10A). Furthermore, high-grade tumors showed increased levels of ANKRD1 compared to low-grade tumors. Both in vitro and in vivo functional studies demonstrated the essential role of ANKRD1 in cancer cell migration and invasion. The previous studies have suggested a significant role of NF-κB and MAGE-A6 in breast cancer metastasis, but the upstream regulators of this axis are not well characterized. Our study suggests that ANKRD1 promotes metastasis of breast cancer by activating NF-κB as well as MAGE-A6 signaling. Our findings show that ANKRD1 is a potential therapeutic target and a diagnostic marker for breast cancer metastasis.
早期发现与手术切除肿瘤有助于提高乳腺癌患者的生存率。然而，转移性癌症患者通常预后较差。本研究提出ANKRD1可促进乳腺癌转移。与非转移性乳腺癌细胞系（MCF-7、ZR-75-30、T47D）及正常乳腺细胞（MCF-10A）相比，ANKRD1在高转移性乳腺癌细胞系MDA-MB-231和MDA-LM-2中呈现高表达。此外，高级别肿瘤中的ANKRD1水平显著高于低级别肿瘤。体外与体内功能研究均证实ANKRD1在癌细胞迁移和侵袭过程中发挥关键作用。既往研究表明NF-κB和MAGE-A6在乳腺癌转移中具有重要作用，但该信号轴的上游调控机制尚未明确。本研究揭示ANKRD1通过激活NF-κB及MAGE-A6信号通路促进乳腺癌转移。研究结果表明，ANKRD1可作为乳腺癌转移的潜在治疗靶点与诊断标志物。
ANKRD1 Promotes Breast Cancer Metastasis by Activating NF-κB-MAGE-A6 Pathway
肿瘤(癌症)患者之家