文章：

放射治疗在头颈部黏膜黑色素瘤治疗中的应用

Radiation Therapy in the Management of Head and Neck Mucosal Melanoma

原文发布日期：27 September 2024

DOI: 10.3390/cancers16193304

类型: Article

开放获取: 是

英文摘要：

Mucosal melanoma of the head and neck (HNMM) is a rare but highly aggressive malignancy, often diagnosed at an advanced stage with poor prognosis. This review discusses current treatment strategies, emphasizing the role of radiotherapy in managing this challenging disease. A comprehensive analysis of 33 studies provides updated information on techniques and outcomes, highlighting the consistent benefit of adjuvant radiation in improving local control. Advances in conformal techniques, such as intensity-modulated radiotherapy (IMRT), have significantly reduced toxicity rates. Preliminary data on proton and carbon ion therapies suggest the potential for further enhancement of the therapeutic ratio, despite limited availability. Although recent studies report 3-year local control rates as high as 90%, overall survival within the same time frame remains well below 50–60%, underscoring the need for continued improvement in systemic therapies to address the persistent issue of distant metastases.

摘要翻译： 

头颈部黏膜黑色素瘤（HNMM）是一种罕见但高度侵袭性的恶性肿瘤，通常在晚期确诊且预后较差。本综述探讨了当前的治疗策略，重点分析了放射治疗在这一棘手疾病管理中的作用。通过对33项研究的综合分析，本文提供了关于治疗技术与疗效的最新信息，强调了辅助放疗在改善局部控制方面具有持续获益。调强放射治疗（IMRT）等适形技术的进步显著降低了毒性反应发生率。质子与碳离子治疗的初步数据显示，尽管应用范围有限，但其可能进一步提升治疗效益比。尽管近期研究报告显示3年局部控制率高达90%，但同期总生存率仍远低于50-60%，这凸显了需要持续改进全身治疗方案以应对远处转移这一长期存在的问题。

原文链接：

Radiation Therapy in the Management of Head and Neck Mucosal Melanoma