Backgroud:Salivary gland tumors (SGTs) are rare and diverse neoplasms, presenting significant challenges in diagnosis and management due to their rarity and complexity. Exosomes, lipid bilayer vesicles secreted by almost all cell types and present in all body fluids, have emerged as crucial intercellular communication agents. They play multifaceted roles in tumor biology, including modulating the tumor microenvironment, promoting metastasis, and influencing immune responses.Results: This review focuses on the role of exosomes in SGT, hypothesizing that novel diagnostic and therapeutic approaches can be developed by exploring the mechanisms through which exosomes influence tumor occurrence and progression. By understanding these mechanisms, we can leverage exosomes as diagnostic and prognostic biomarkers, and target them for therapeutic interventions. The exploration of exosome-mediated pathways contributing to tumor progression and metastasis could lead to more effective treatments, transforming the management of SGT and improving patient outcomes. Ongoing research aims to elucidate the specific cargo and signaling pathways involved in exosome-mediated tumorigenesis and to develop standardized techniques for exosome-based liquid biopsies in clinical settings.Conclusions:Exosome-based liquid biopsies have shown promise as non-invasive, real-time systemic profiling tools for tumor diagnostics and prognosis, offering significant potential for enhancing patient care through precision and personalized medicine. Methods like fluorescence, electrochemical, colorimetric, and surface plasmon resonance (SPR) biosensors, combined with artificial intelligence, improve exosome analysis, providing rapid, precise, and clinically valid cancer diagnostics for difficult-to-diagnose cancers.
背景：唾液腺肿瘤（SGTs）是一类罕见且异质性强的肿瘤，由于其罕见性和复杂性，在诊断和治疗方面均面临重大挑战。外泌体是由几乎所有细胞类型分泌并存在于所有体液中的脂质双层囊泡，已成为关键的细胞间通讯介质。它们在肿瘤生物学中扮演多重角色，包括调节肿瘤微环境、促进转移以及影响免疫应答。 结果：本综述聚焦于外泌体在唾液腺肿瘤中的作用，提出通过探索外泌体影响肿瘤发生与进展的机制，有望开发出新的诊断与治疗方法。通过理解这些机制，我们可以将外泌体用作诊断和预后的生物标志物，并将其作为治疗干预的靶点。对外泌体介导的促进肿瘤进展和转移通路的探索，可能带来更有效的治疗手段，从而改变唾液腺肿瘤的治疗策略并改善患者预后。当前研究旨在阐明外泌体介导肿瘤发生所涉及的具体内容物和信号通路，并开发用于临床的外泌体液体活检标准化技术。 结论：基于外泌体的液体活检作为一种非侵入性、实时系统分析工具，在肿瘤诊断和预后方面展现出潜力，为通过精准和个性化医疗提升患者护理水平提供了重要前景。荧光、电化学、比色和表面等离子体共振（SPR）等生物传感技术，结合人工智能的应用，改进了外泌体分析，为难以诊断的癌症提供了快速、精确且临床有效的诊断方法。
Role of Exosomes in Salivary Gland Tumors and Technological Advances in Their Assessment
肿瘤(癌症)患者之家