Objectives:Adverse childhood experiences (ACEs) are linked to a heightened risk of depression. We explored the relationship between ACEs and both depression and mental distress among cancer survivors.Methods:This was a cross-sectional analysis using the 2022 Behavioral Risk Factor Surveillance System database of cancer survivors aged ≥18 (n = 14,132). The primary outcome was self-reported history of depression, and the secondary outcome was mental distress. The exposure variable was the number of ACEs, classified as 0, 1–2, and ≥3. Weighted multivariable logistic regression models assessed the association between the number of ACEs and depression and mental distress while adjusting for covariates.Results:Approximately 22% of respondents reported experiencing ≥3 ACEs. The prevalence of depression was 21.8%, and mental distress was 15.4%. Compared with cancer survivors who had experienced 0 ACEs, those who had experienced ≥3 (aOR = 3.94; 95% CI, 3.04–5.10) or 1–2 (aOR = 1.85; 95% CI, 1.47–2.32) ACEs had a higher likelihood of reporting depression. Compared with cancer survivors who had experienced 0 ACEs, those who had experienced ≥3 (aOR = 0.67; 95% CI, 0.48–0.93) had a lower likelihood of reporting mental distress.Conclusions:This study highlights the impact of ACEs on depression in adulthood among cancer survivors.
目的：不良童年经历与抑郁症风险升高相关。本研究探讨了癌症幸存者中不良童年经历与抑郁症及心理困扰之间的关系。 方法：本研究采用横断面分析方法，利用2022年行为风险因素监测系统中18岁及以上癌症幸存者数据（n = 14,132）。主要结局指标为自我报告的抑郁症病史，次要结局指标为心理困扰。暴露变量为不良童年经历数量，分为0、1-2和≥3个等级。通过加权多变量逻辑回归模型评估不良童年经历数量与抑郁症及心理困扰的关联性，并对协变量进行调整。 结果：约22%的受访者报告经历≥3次不良童年经历。抑郁症患病率为21.8%，心理困扰发生率为15.4%。与未经历不良童年经历的癌症幸存者相比，经历≥3次（调整后比值比 = 3.94；95%置信区间，3.04-5.10）或1-2次（调整后比值比 = 1.85；95%置信区间，1.47-2.32）不良童年经历的幸存者报告抑郁症的可能性显著更高。而经历≥3次不良童年经历的幸存者（调整后比值比 = 0.67；95%置信区间，0.48-0.93）报告心理困扰的可能性低于未经历者。 结论：本研究揭示了不良童年经历对癌症幸存者成年期抑郁症的重要影响。
肿瘤(癌症)患者之家