文章：

短肽：智能抗癌的强大武器库

Short Peptides as Powerful Arsenal for Smart Fighting Cancer

原文发布日期：24 September 2024

DOI: 10.3390/cancers16193254

类型: Article

开放获取: 是

英文摘要：

Short peptides have been coming around as a strong weapon in the fight against cancer on all fronts—in immuno-, chemo-, and radiotherapy, and also in combinatorial approaches. Moreover, short peptides have relevance in cancer imaging or 3D culture. Thanks to the natural ‘smart’ nature of short peptides, their unique structural features, as well as recent progress in biotechnological and bioinformatics development, short peptides are playing an enormous role in evolving cutting-edge strategies. Self-assembling short peptides may create excellent structures to stimulate cytotoxic immune responses, which is essential for cancer immunotherapy. Short peptides can help establish versatile strategies with high biosafety and effectiveness. Supramolecular short peptide-based cancer vaccines entered clinical trials. Peptide assemblies can be platforms for the delivery of antigens, adjuvants, immune cells, and/or drugs. Short peptides have been unappreciated, especially in the vaccine aspect. Meanwhile, they still hide the undiscovered unlimited potential. Here, we provide a timely update on this highly active and fast-evolving field.

摘要翻译： 

短肽正逐渐成为抗癌斗争中的有力武器，在免疫疗法、化疗、放疗以及联合治疗策略中均展现出重要作用。此外，短肽在癌症成像及三维细胞培养领域也具有重要应用价值。得益于其天然的“智能”特性、独特的结构特征，以及生物技术与生物信息学的最新进展，短肽在推动前沿抗癌策略发展中正发挥着巨大作用。自组装短肽能够构建出优异的结构以激发细胞毒性免疫反应，这对于癌症免疫治疗至关重要。短肽有助于建立兼具高生物安全性和高效性的多样化治疗策略。基于超分子短肽的癌症疫苗已进入临床试验阶段。肽组装体可作为抗原、佐剂、免疫细胞及药物的递送平台。短肽的潜力，尤其在疫苗领域，长期未被充分重视，其仍蕴藏着尚未被发掘的无限可能。本文旨在对这一高度活跃且快速发展的领域提供及时的研究进展综述。

原文链接：

Short Peptides as Powerful Arsenal for Smart Fighting Cancer