文章：

肝细胞癌中门静脉血栓形成的分子机制

The Molecular Mechanisms of Portal Vein Thrombosis in Hepatocellular Carcinoma

原文发布日期：24 September 2024

DOI: 10.3390/cancers16193247

类型: Article

开放获取: 是

英文摘要：

Hepatocellular carcinoma (HCC) represents the sixth most diagnosed cancer worldwide and is the second leading cause of cancer-related death in the world. The association of HCC and portal vein thrombosis (PVT) represents an advanced stage of the tumor. PVT has a prevalence of about 25–50% in HCC, determining poor prognosis and a remarkable reduction in therapeutic perspectives in these patients, leading to severe complications such as ascites, metastasis, an increase in portal hypertension and potentially fatal gastrointestinal bleeding. The aim of this review is to evaluate the molecular mechanisms that are at the basis of PVT development, trying to evaluate possible strategies in the early detection of patients at high risk of PVT.

摘要翻译： 

肝细胞癌（HCC）是全球第六大常见癌症，也是癌症相关死亡的第二大原因。HCC合并门静脉血栓（PVT）标志着肿瘤已进入晚期阶段。在HCC患者中，PVT的发生率约为25%-50%，这导致患者预后不良，治疗前景显著受限，并可能引发腹水、转移、门静脉高压加剧及潜在致命性胃肠道出血等严重并发症。本综述旨在探讨PVT形成的分子机制，并尝试评估早期识别PVT高风险患者的潜在策略。

原文链接：

The Molecular Mechanisms of Portal Vein Thrombosis in Hepatocellular Carcinoma