Background/Objectives: Due to an increased rate of surveillance colonoscopy, we aim to determine the impact of stage migration on the incidence and overall survival (OS) of patients who underwent pathological staging of colorectal cancer (CRC) at our Health Network System. Methods: Two datasets were included: subjects from the tumor registry at a regional Comprehensive Cancer Center(n= 1385) and subjects from the Surveillance, Epidemiology, and End Results (SEER) national database (n= 202,391). Results: A significant increase in the diagnosis of CRC Stage 1 and 4 was observed, with a decrease in stage 2, and no change in Stage 3 in the National datasets (p< 0.01). There was an increase in Stage 4 CRC diagnosis, with a concurrent decrease in stage 2, and no changes in stages 1 and 3 in the regional dataset (p< 0.05). OS followed the expected and progressive decrease in OS by stage (from 1 to 4,p< 0.01). Conclusions: The present findings confirmed CRC stage migration in our Health Network System, along with a national trend conducive to an increased OS for early CRC stages.
背景/目的：随着监测性结肠镜检查率的提高，本研究旨在评估分期迁移对我们医疗网络系统中接受结直肠癌病理分期患者的发病率及总生存期的影响。方法：研究纳入两个数据集：区域综合癌症中心肿瘤登记库的病例（n=1385）以及美国国家癌症研究所监测、流行病学和最终结果数据库的病例（n=202,391）。结果：全国数据显示，结直肠癌Ⅰ期和Ⅳ期诊断率显著上升，Ⅱ期下降，Ⅲ期无变化（p<0.01）；区域数据显示Ⅳ期诊断率上升，Ⅱ期下降，Ⅰ期和Ⅲ期无显著变化（p<0.05）。各分期总生存期呈现从Ⅰ期到Ⅳ期逐级递减的预期趋势（p<0.01）。结论：本研究证实了我们医疗网络系统中存在的结直肠癌分期迁移现象，且全国数据显示早期结直肠癌总生存期提升的趋势。
Incidence and Dynamics of CRC Stage Migration: A Regional vs. a National Analysis
肿瘤(癌症)患者之家