11C-Methionine (MET) is a widely utilized amino acid tracer in positron emission tomography (PET) imaging of primary brain tumors. 11C-MET PET offers valuable insights for tumor classification, facilitates treatment planning, and aids in monitoring therapeutic response. Its tracer properties allow better delineation of the active tumor volume, even in regions that show no contrast enhancement on conventional magnetic resonance imaging (MRI). This review focuses on the role of MET-PET in brain glioma imaging. The introduction provides a brief clinical overview of the problems of high-grade and recurrent gliomas. It discusses glioma management, radiotherapy planning, and the difficulties of imaging after chemoradiotherapy (pseudoprogression or radionecrosis). The mechanism of MET-PET is described. Additionally, the review encompasses the application of MET-PET in the context of primary gliomas, addressing its diagnostic precision, utility in tumor classification, prognostic value, and role in guiding biopsy procedures and radiotherapy planning.
11C-蛋氨酸（MET）是原发性脑肿瘤正电子发射断层扫描（PET）成像中广泛应用的氨基酸示踪剂。11C-MET PET为肿瘤分类提供了重要依据，有助于治疗规划，并辅助监测治疗效果。其示踪特性使得即使在传统磁共振成像（MRI）上未显示对比增强的区域，也能更清晰地勾画出活性肿瘤体积。本综述重点探讨MET-PET在脑胶质瘤成像中的作用。引言部分简要概述了高级别和复发性胶质瘤的临床问题，讨论了胶质瘤的治疗管理、放疗规划以及放化疗后成像的困难（如假性进展或放射性坏死）。文中阐述了MET-PET的作用机制，并综述了MET-PET在原发性胶质瘤中的应用，包括其诊断准确性、在肿瘤分类中的实用性、预后价值以及在指导活检程序和放疗规划中的作用。
Value of 11C-Methionine PET Imaging in High-Grade Gliomas: A Narrative Review
肿瘤(癌症)患者之家