Objectives: Classic Kaposi’s sarcoma (CKS) is a rare malignancy with diverse clinical presentations, lacking a standard treatment. While localized therapies are commonly used for symptomatic lesions, radiotherapy (RT) has demonstrated effectiveness. This study aims to evaluate the efficacy of RT for treating skin lesions in CKS. Methods: A retrospective analysis was conducted on patients with KS treated between April 2012 and January 2024. In total, 69 lesions in 16 patients were included. Treatment response was defined as follows: complete response (CR) indicated the absence of clinically detectable skin lesions and symptoms; partial response (PR) was a reduction in lesion height by more than half or a lighter lesion color compared to before treatment. In-field recurrence was the appearance of new lesions within a previously irradiated field. Logistic regression analysis was used to investigate factors influencing response and in-field recurrence. Results: The median follow-up period was 52 months (range, 3–138 months). The overall response rate was 100%, with 92.8% of the patients achieving CR and 7.2% receiving PR. PR was observed in three patients with five lesions, all of which remained stable. In-field recurrence occurred in two patients with initially advanced disease, and all recurrent lesions responded to RT. No variables were significantly associated with response or in-field recurrence. Conclusions: RT for CKS showed a 100% response rate, with complete symptom relief in all cases. The effectiveness of RT was evident, even in cases involving disseminated lesions. Further research is needed to determine the optimal RT dose and fractionation.
目的：经典型卡波西肉瘤（CKS）是一种临床表现多样的罕见恶性肿瘤，目前缺乏标准治疗方案。虽然局部治疗常用于处理症状性病灶，但放射治疗（RT）已显示出疗效。本研究旨在评估RT治疗CKS皮肤病灶的有效性。方法：对2012年4月至2024年1月期间接受治疗的KS患者进行回顾性分析，共纳入16例患者的69处病灶。治疗反应定义如下：完全缓解（CR）指临床可检测的皮肤病灶及症状完全消失；部分缓解（PR）指病灶高度较治疗前减少超50%或病灶颜色变浅。野内复发指既往照射野内出现新病灶。采用逻辑回归分析探讨影响治疗反应及野内复发的因素。结果：中位随访时间为52个月（范围3-138个月）。总体缓解率达100%，其中92.8%患者达到CR，7.2%患者获得PR。在3例患者的5处病灶中观察到PR，所有病灶均保持稳定。2例初始晚期疾病患者出现野内复发，所有复发灶对RT均产生应答。未发现与治疗反应或野内复发显著相关的变量。结论：RT治疗CKS的缓解率达100%，所有病例症状均完全缓解。即使在播散性病灶病例中，RT的疗效依然显著。未来需进一步研究以确定最佳RT剂量与分割方案。
肿瘤(癌症)患者之家