Endometrial cancer (EC) is the most common gynecological malignancy. EC is associated with metabolic disorders that may promote non-enzymatic glycation and activate the receptor for advanced glycation end-products (RAGE) signaling pathways. Thus, we assumed that RAGE and its ligands may contribute to EC. Of particular interest is the interaction between diaphanous-related formin 1 (Diaph1) and RAGE during the progression of human cancers. Diaph1 is engaged in the proper organization of actin cytoskeletal dynamics, which is crucial in cancer invasion, metastasis, angiogenesis, and axonogenesis. However, the detailed molecular role of RAGE in EC remains uncertain. In this review, we discuss epigenetic factors that may play a key role in the RAGE-dependent endometrial pathology. We propose that DNA methylation may regulate the activity of the RAGE pathway in the uterus. The accumulation of negative external factors, such as hyperglycemia, inflammation, and oxidative stress, may interfere with the DNA methylation process. Therefore, further research should take into account the role of epigenetic mechanisms in EC progression.
子宫内膜癌（EC）是最常见的妇科恶性肿瘤。EC与代谢紊乱相关，这些紊乱可能促进非酶糖基化并激活晚期糖基化终末产物受体（RAGE）信号通路。因此，我们推测RAGE及其配体可能在EC的发生发展中发挥作用。尤其值得关注的是，在人类癌症进展过程中，透明相关formin 1（Diaph1）与RAGE之间的相互作用。Diaph1参与肌动蛋白细胞骨架动力学的正确组织，这对癌症侵袭、转移、血管生成和轴突生成至关重要。然而，RAGE在EC中的具体分子作用仍不明确。本综述讨论了可能在RAGE依赖性子宫内膜病理中起关键作用的表观遗传因素。我们提出，DNA甲基化可能调控子宫中RAGE通路的活性。高血糖、炎症和氧化应激等负面外部因素的积累可能干扰DNA甲基化过程。因此，进一步研究应考虑表观遗传机制在EC进展中的作用。
Role of Receptor for Advanced Glycation End-Products in Endometrial Cancer: A Review
肿瘤(癌症)患者之家