Colorectal cancer (CRC) remains a significant global health burden with high incidence and mortality. MicroRNAs (miRNAs) are small non-protein coding transcripts, conserved throughout evolution, with an important role in CRC tumorigenesis, and are either upregulated or downregulated in various cancers. RNA-binding proteins (RBPs) are known as essential regulators of miRNA activity. Human antigen R (HuR) is a prominent RBP known to drive tumorigenesis with a pivotal role in CRC. In this review, we discuss the regulatory role of the HuR/miRNA axis in CRC. Interestingly, miRNAs can directly target HuR, altering its expression and activity. However, HuR can also stabilize or degrade miRNAs, forming complex feedback loops that either activate or block CRC-associated signaling pathways. Dysregulation of the HuR/miRNA axis contributes to CRC initiation and progression. Additionally, HuR-miRNA regulation by other small non-coding RNAs, circular RNA (circRNAs), or long-non-coding RNAs (lncRNAs) is also explored here. Understanding this HuR-miRNA interplay could reveal novel biomarkers with better diagnostic or prognostic accuracy.
结直肠癌（CRC）作为全球重大健康负担，其发病率和死亡率居高不下。微小RNA（miRNA）是一类在进化中高度保守的非编码小分子转录本，在结直肠癌发生发展中发挥重要作用，并在多种癌症中呈现上调或下调表达。RNA结合蛋白（RBP）是miRNA活性的关键调控因子，其中人抗原R（HuR）作为重要的RBP在结直肠癌发生中起驱动作用。本综述系统探讨HuR/miRNA调控轴在结直肠癌中的作用机制。值得注意的是，miRNA可直接靶向HuR并改变其表达与活性，而HuR亦能稳定或降解miRNA，形成复杂的反馈环路，从而激活或阻断结直肠癌相关信号通路。该调控轴的失调促进结直肠癌的发生发展。此外，本文还探讨了环状RNA（circRNA）和长链非编码RNA（lncRNA）等其他非编码RNA对HuR-miRNA通路的调控作用。深入解析HuR与miRNA的相互作用机制，有望为结直肠癌诊疗提供新型生物标志物，提升疾病诊断与预后评估的精准度。
Unraveling the Regulatory Role of HuR/microRNA Axis in Colorectal Cancer Tumorigenesis
肿瘤(癌症)患者之家