In recent years, ultrasound-stimulated microbubbles (USMBs) have gained great attention because of their wide theranostic applications. However, due to their micro-size, reaching the targeted site remains a challenge. At present, ultrasound-stimulated nanobubbles (USNBs) have attracted particular interest, and their small size allows them to extravasate easily in the blood vessels penetrating deeper into the tumor vasculature. Incorporating USNBs with existing cancer therapies such as chemotherapy, immunotherapy, and/or radiation therapy in several preclinical models has been demonstrated to have a profound effect on solid tumors. In this review, we provide an understanding of the composition and formation of nanobubbles (NBs), followed by the recent progress of the therapeutic combinatory effect of USNBs and other cancer therapies in cancer treatment.
近年来，超声刺激微泡因其广泛的热诊疗应用而备受关注。然而，由于其微米级尺寸，到达靶向部位仍面临挑战。目前，超声刺激纳米泡引起了特别关注，其微小尺寸使其易于在血管中渗出，更深入地穿透肿瘤血管系统。在多种临床前模型中，将超声刺激纳米泡与现有癌症疗法（如化疗、免疫治疗和/或放射治疗）相结合，已被证明对实体肿瘤具有深远影响。本综述旨在阐述纳米泡的组成与形成机制，并重点介绍超声刺激纳米泡与其他癌症疗法联合治疗的最新进展。
肿瘤(癌症)患者之家