(1) Background: Head and neck paragangliomas are neuroendocrine tumors that typically originate from the parasympathetic nervous system and are predominantly non-secretory. Their clinical manifestations result from their mass effect on the surrounding tissues. The approach to treating these tumors depends on factors such as their location, size, impact on adjacent structures, and the patient’s overall health and preferences. (2) Methods: A retrospective analysis of the management of temporal bone paraganglioma classes A and B (according to the modified Fisch classification) was performed at the University Medical Centre, Ljubljana, between 2011 and 2023. (3) Results: We analyzed 23 cases, 19 of which underwent surgery; complete tumor removal was achieved in 18 of them. Four patients were irradiated due to tumor progression to class C. Three of these four patients initially refused surgery and were treated with radiotherapy (RT) 7, 13, and 18 years after diagnosis. In the fourth patient, complete surgical resection was not achieved and she was treated with RT four years after surgery, due to the growth of the tumor to class C. The average follow-up time from diagnosis was 8.9 years (median 6 years; range 1–26 years). (4) Conclusions: The surgical treatment of patients with class A and B paragangliomas is effective and safe. In cases where surgery is refused but the tumor continues to grow to class C, RT is an alternative and efficient method of controlling tumor growth.
（1）背景：头颈部副神经节瘤是一种神经内分泌肿瘤，通常起源于副交感神经系统，且多为非分泌型。其临床表现源于肿瘤对周围组织的占位效应。治疗这类肿瘤的方法取决于多种因素，包括肿瘤的位置、大小、对邻近结构的影响，以及患者的整体健康状况和个人意愿。（2）方法：对卢布尔雅那大学医学中心2011年至2023年间收治的颞骨副神经节瘤A类和B类（依据改良Fisch分级）病例的治疗情况进行了回顾性分析。（3）结果：共分析了23例病例，其中19例接受了手术治疗，其中18例实现了肿瘤完全切除。4例患者因肿瘤进展至C类接受了放射治疗。这4例患者中有3例最初拒绝手术，分别在确诊后7年、13年和18年接受了放疗。第4例患者因手术未能完全切除肿瘤，术后四年因肿瘤生长至C类而接受了放疗。从确诊起的平均随访时间为8.9年（中位数6年；范围1-26年）。（4）结论：对于A类和B类副神经节瘤患者，手术治疗是有效且安全的。若患者拒绝手术但肿瘤持续生长至C类，放疗可作为控制肿瘤生长的替代且有效的方法。
Clinical Characteristics and Outcomes of Tympanomastoid Paragangliomas: A Report from Slovenia
肿瘤(癌症)患者之家