文章：

日本患者幽门螺杆菌根除后早期胃癌的临床病理特征：早期（<10年）与晚期（>10年）发病的比较研究

Clinicopathologic Features of Early Gastric Cancer afterHelicobacter pyloriEradication in Japanese Patients: Comparative Study between Early (<10 Years) and Late (>10 Years) Onset

原文发布日期：14 September 2024

DOI: 10.3390/cancers16183154

类型: Article

开放获取: 是

英文摘要：

Background/Objectives: Eradication therapy forHelicobacter pylorigastritis was approved for insurance coverage by the Japanese government in 2013. Since then, the incidence of gastric cancer discovered after eradication (GCAE) has increased. However, there are only a few reports of GCAE diagnosed more than 10 years after eradication. We investigated the clinicopathological characteristics of early-stage GCAE, including histological types and the interval from eradication to diagnosis. Methods: Overall, 379 patients with a total of 448 GCAE lesions treated with endoscopic resection or surgery at our hospital between January 2015 and December 2021 were assessed, and 315 patients with a known interval from eradication to diagnosis of GCAE with a total of 354 lesions were included. We classified the cases into two groups: differentiated-type GCAE (D-GCAE; 279 patients, 318 lesions) and undifferentiated-type GCAE (UD-GCAE; 36 patients, 36 lesions). Results: Smoking and a mild-to-moderate degree of atrophy were risk factors associated with differentiated-type gastric cancer occurring more than 10 years afterH. pylorieradication. Additionally, the rate of a mixture of histological types with relatively high malignant potential was significantly higher in UD-GCAE presenting more than 10 years after eradication group than those presenting within 10 years after eradication.

摘要翻译： 

背景/目的：日本政府于2013年批准将幽门螺杆菌胃炎根除治疗纳入医保范围。此后，根除后发现的胃癌（GCAE）发病率有所上升。然而，关于根除治疗10年后才被诊断出的GCAE病例报告较少。本研究旨在探讨早期GCAE的临床病理特征，包括组织学类型以及从根除治疗到诊断的时间间隔。方法：我们评估了2015年1月至2021年12月期间在我院接受内镜切除或手术治疗的379例患者，共计448个GCAE病灶，其中315例患者（共计354个病灶）已知从根除治疗到GCAE诊断的时间间隔。我们将病例分为两组：分化型GCAE（D-GCAE；279例患者，318个病灶）和未分化型GCAE（UD-GCAE；36例患者，36个病灶）。结果：吸烟以及轻至中度胃萎缩是幽门螺杆菌根除治疗10年后发生分化型胃癌的相关风险因素。此外，在根除治疗10年后出现的UD-GCAE中，组织学类型混合且恶性潜能相对较高的比例显著高于根除治疗后10年内出现的病例。

原文链接：

Clinicopathologic Features of Early Gastric Cancer afterHelicobacter pyloriEradication in Japanese Patients: Comparative Study between Early (<10 Years) and Late (>10 Years) Onset