文章：

胃肠道癌症中的炎症相关干细胞：作为预后生物标志物与治疗靶点的应用价值

Inflammation-Associated Stem Cells in Gastrointestinal Cancers: Their Utility as Prognostic Biomarkers and Therapeutic Targets

原文发布日期：12 September 2024

DOI: 10.3390/cancers16183134

类型: Article

开放获取: 是

英文摘要：

Stem cells are critical for the development and homeostasis of the gastrointestinal (GI) tract. Inflammatory molecules are known to regulate the activity of stem cells. A comprehensive review specifically describing the role of inflammatory molecules in the regulation of stem cells within the GI tract and in GI cancers (GICs) is not available. This review focuses on understanding the role of inflammatory molecules and stem cells in maintaining homeostasis of the GI tract. We further discuss how inflammatory conditions contribute to the transformation of stem cells into tumor-initiating cells. We also describe the molecular mechanisms of inflammation and stem cell-driven progression and metastasis of GICs. Furthermore, we report on studies describing the prognostic value of cancer stem cells and the clinical trials evaluating their therapeutic utility. This review provides a detailed overview on the role of inflammatory molecules and stem cells in maintaining GI tract homeostasis and their implications for GI-related malignancies

摘要翻译： 

干细胞对于胃肠道的发育与稳态维持至关重要。已知炎症分子能够调控干细胞活性。目前尚缺乏专门阐述炎症分子在胃肠道及胃肠道癌症中调控干细胞作用的系统性综述。本综述旨在深入探讨炎症分子与干细胞在维持胃肠道稳态中的作用机制，进一步阐述炎症环境如何促使干细胞转化为肿瘤起始细胞，并详细解析炎症与干细胞驱动胃肠道癌症进展及转移的分子机制。此外，我们汇总了关于癌症干细胞预后价值的研究报道，以及评估其治疗潜力的临床试验进展。本综述系统阐述了炎症分子与干细胞在维持胃肠道稳态中的作用及其对胃肠道恶性肿瘤发生发展的影响。

原文链接：

Inflammation-Associated Stem Cells in Gastrointestinal Cancers: Their Utility as Prognostic Biomarkers and Therapeutic Targets