Cisplatin is one of the most well-known anti-cancer drugs and has demonstrated efficacy against numerous tumor types for many decades. However, a key challenge with cisplatin, as with any chemotherapeutic agent, is the development of resistance with a resultant loss of efficacy. This resistance is often associated with metabolic alterations that allow insensitive cells to divide and survive under treatment. These adaptations could vary greatly among different tumor types and may seem questionable and incomprehensible at first glance. Here we discuss the disturbances in glucose, lipid, and amino acid metabolism in cisplatin-resistant cells as well as the roles of ferroptosis and autophagy in acquiring this type of drug intolerance.
顺铂是最广为人知的抗癌药物之一，数十年来已证明对多种肿瘤类型具有显著疗效。然而，与所有化疗药物一样，顺铂面临的关键挑战在于耐药性的产生及其导致的疗效丧失。这种耐药性通常与代谢改变相关，使得不敏感细胞能够在治疗条件下持续分裂与存活。不同肿瘤类型的代谢适应机制差异显著，初看之下甚至可能显得矛盾且难以理解。本文系统探讨顺铂耐药细胞中葡萄糖、脂质及氨基酸代谢的紊乱现象，并深入分析铁死亡与自噬在获得此类药物耐受性中的作用机制。
Cisplatin Resistance and Metabolism: Simplification of Complexity
肿瘤(癌症)患者之家