Breast cancer (BC) continues to significantly impact women worldwide. Numerous studies show that physical activity (PA) significantly enhances the quality of life, aids recovery, and improves survival rates in BC patients. PA’s influence extends to altering DNA methylation patterns on both a global and gene-specific scale, potentially reverting abnormal DNA methylation, associated with carcinogenesis and various pathologies. This review consolidates the findings of the current literature, highlighting PA’s impact on DNA methylation in BC patients. Our systematic analysis indicates that PA may elevate global DNA methylation within tumour tissues. Furthermore, it appears to modify gene-specific promoter methylation across a wide spectrum of genes in various tissues. Through bioinformatic analysis, to investigate the functional enrichment of these affected genes, we identified a predominant enrichment in metabolic pathways, cell cycle regulation, cell cycle checkpoints, mitosis, cellular stress responses, and molecular functions governing diverse binding processes. The Human Protein Atlas corroborates this enrichment, indicating gene functionality across 266 tissues, notably within various breast tissues. This systematic review unveils PA’s capacity to systematically alter DNA methylation patterns across multiple tissues, particularly in BC patients. Emphasising its influence on crucial biological processes and functions, this alteration holds potential for restoring normal cellular functionality and the cell cycle. This reversal of cancer-associated patterns could potentially enhance recovery and improve survival outcomes.
乳腺癌持续对全球女性健康构成显著影响。多项研究表明，体力活动能显著提升乳腺癌患者的生活质量、促进康复并提高生存率。体力活动的影响机制涉及在整体和基因特异性层面改变DNA甲基化模式，可能逆转与癌变及多种病理过程相关的异常DNA甲基化。本综述整合现有文献研究结果，重点探讨体力活动对乳腺癌患者DNA甲基化的影响。系统分析表明，体力活动可能提高肿瘤组织中的整体DNA甲基化水平，并能在多种组织中广泛调节基因特异性启动子甲基化状态。通过生物信息学分析这些受影响基因的功能富集情况，我们发现其主要富集于代谢通路、细胞周期调控、细胞周期检查点、有丝分裂、细胞应激反应以及调控多种结合过程的分子功能。人类蛋白质图谱数据库证实了这种富集模式，显示相关基因在266种组织中具有功能活性，尤其在各类乳腺组织中表现显著。本系统综述揭示了体力活动能够系统性地改变多组织DNA甲基化模式，特别是在乳腺癌患者中。这种改变对关键生物过程和功能的影响，可能有助于恢复正常细胞功能与细胞周期。这种癌症相关模式的逆转有望促进患者康复并改善生存预后。
肿瘤(癌症)患者之家