文章：

泛素结合酶E2 O（UBE2O）及其在人类白血病与实体瘤中的治疗潜力

The Ubiquitin-Conjugating Enzyme E2 O (UBE2O) and Its Therapeutic Potential in Human Leukemias and Solid Tumors

原文发布日期：3 September 2024

DOI: 10.3390/cancers16173064

类型: Article

开放获取: 是

英文摘要：

Protein degradation is a biological phenomenon essential for cellular homeostasis and survival. Selective protein degradation is performed by the ubiquitination system which selectively targets proteins that need to be eliminated and leads them to proteasome degradation. In this narrative review, we focus on the ubiquitin-conjugating enzyme E2 O (UBE2O) and highlight the role of UBE2O in many biological and physiological processes. We further discuss UBE2O’s implications in various human diseases, particularly in leukemias and solid cancers. Ultimately, our review aims to highlight the potential role of UBE2O as a therapeutic target and offers new perspectives for developing targeted treatments for human cancers.

摘要翻译： 

蛋白质降解是维持细胞稳态与生存至关重要的生物学现象。选择性蛋白质降解由泛素化系统执行，该系统能特异性识别需要清除的蛋白质并引导其进入蛋白酶体降解途径。本文聚焦泛素结合酶E2 O（UBE2O），系统阐述其在多种生物及生理过程中的关键作用，深入探讨UBE2O在人类疾病（特别是白血病与实体肿瘤）发生发展中的病理学意义。最终，本综述旨在揭示UBE2O作为治疗靶点的潜在价值，为开发癌症靶向治疗策略提供新视角。

原文链接：

The Ubiquitin-Conjugating Enzyme E2 O (UBE2O) and Its Therapeutic Potential in Human Leukemias and Solid Tumors