Breast cancer is one of the most common cancers and the leading cause of cancer death in women. Less than 1% of breast cancer cases are male breast cancers. Although there has been significant progress made in the management of breast cancer, due to its rarity among men, the question of whether men and women with breast cancer have the same treatment response and survival rate still needs to be answered. The primary goal of this study is to compare survival outcomes between male and female breast cancer patients. Material and Method: This cohort study represents a retrospective and anonymized data analysis of 2162 breast cancer cases (19 males and 2143 females), registered over a period of 12 years, from 1 January 2010 to 31 December 2021, in the Clinic of Obstetrics and Gynecology, Diakoneo Diak Klinikum Schwäbisch Hall, Germany. Results: According to the Kaplan–Meier survival analysis, the estimated overall 3-year survival rate was 91.1% for women and 88.9% for men. The log-rank test of equality of survival distributions indicated a statistically significant difference in survival times between the two groups (p= 0.009). In the subsequent age-matched Kaplan–Meier analysis, thep-value was below the significance threshold (p= 0.068). Conclusions: Male breast cancer is a rare disease that may show some particularities in terms of survival compared to female breast cancer.
乳腺癌是最常见的癌症之一，也是女性癌症死亡的主要原因。男性乳腺癌病例占所有乳腺癌病例的比例不足1%。尽管乳腺癌治疗已取得显著进展，但由于其在男性中的罕见性，男性和女性乳腺癌患者是否具有相同的治疗反应和生存率仍有待解答。本研究的主要目的是比较男性和女性乳腺癌患者的生存结局。材料与方法：本队列研究对德国迪亚科内奥迪亚克施瓦本哈尔医院妇产科2010年1月1日至2021年12月31日期间登记的2162例乳腺癌病例（19例男性和2143例女性）进行了回顾性匿名数据分析。结果：根据Kaplan-Meier生存分析，女性患者的估计3年总生存率为91.1%，男性为88.9%。生存分布相等的对数秩检验显示两组间生存时间存在统计学显著差异（p=0.009）。在随后的年龄匹配Kaplan-Meier分析中，p值低于显著性阈值（p=0.068）。结论：男性乳腺癌是一种罕见疾病，与女性乳腺癌相比，其在生存方面可能表现出某些特殊性。
Observational Study of Men and Women with Breast Cancer in Terms of Overall Survival
肿瘤(癌症)患者之家