文章：

脑膜瘤患者癫痫发作的预测因素

Predictors for the Occurrence of Seizures in Meningioma

原文发布日期：31 August 2024

DOI: 10.3390/cancers16173046

类型: Article

开放获取: 是

英文摘要：

Seizure is a common symptom of meningioma that has a major impact on patients’ quality of life. The purpose of this study was to identify predictive factors for the occurrence of preoperative and postoperative seizures. The data of patients with resection of histologically confirmed meningioma at University Hospital Leipzig from 2009 to 2018 were retrospectively examined. Univariate and multivariate logistic regression analyses of different factors influencing seizure outcome were performed. The male gender was identified as an independent positive predictor for preoperative seizures (odds ratio [OR] 1.917 [95% confidence interval {CI} 1.044–3.521],p= 0.036), whereas headache (OR 0.230 [95% CI 0.091–0.582],p= 0.002) and neurological deficits (OR 0.223; [95% CI 0.121–0.410],p< 0.001) were demonstrated to be negative predictive factors. Sensorimotor deficit after surgery (OR 4.490 [95% CI 2.231–9.037],p< 0.001) was found to be a positive predictor for the occurrence of postoperative seizures. The identified predictors for the occurrence of seizures in meningioma can contribute to improving seizure treatment and patients’ quality of life.

摘要翻译： 

癫痫是脑膜瘤的常见症状，对患者生活质量有重大影响。本研究旨在识别术前及术后癫痫发作的预测因素。回顾性分析了2009年至2018年间在莱比锡大学医院经组织学确诊并行切除术的脑膜瘤患者资料，采用单因素及多因素逻辑回归分析评估不同因素对癫痫结局的影响。结果显示：男性是术前癫痫发作的独立正向预测因素（比值比[OR] 1.917 [95%置信区间{CI} 1.044–3.521]，p=0.036），而头痛（OR 0.230 [95% CI 0.091–0.582]，p=0.002）和神经功能缺损（OR 0.223 [95% CI 0.121–0.410]，p<0.001）为负向预测因素。术后感觉运动障碍（OR 4.490 [95% CI 2.231–9.037]，p<0.001）是术后癫痫发作的正向预测因素。这些脑膜瘤癫痫发作预测因素的发现，有助于改善癫痫治疗并提升患者生活质量。

原文链接：

Predictors for the Occurrence of Seizures in Meningioma