文章：

微生物组——乳腺稳态与癌症转移的隐形调控者

Microbiome—Stealth Regulator of Breast Homeostasis and Cancer Metastasis

原文发布日期：31 August 2024

DOI: 10.3390/cancers16173040

类型: Article

开放获取: 是

英文摘要：

Cumulative evidence attests to the essential roles of commensal microbes in the physiology of hosts. Although the microbiome has been a major research subject since the time of Luis Pasteur and William Russell over 140 years ago, recent findings that certain intracellular bacteria contribute to the pathophysiology of healthy vs. diseased tissues have brought the field of the microbiome to a new era of investigation. Particularly, in the field of breast cancer research, breast-tumor-resident bacteria are now deemed to be essential players in tumor initiation and progression. This is a resurrection of Russel’s bacterial cause of cancer theory, which was in fact abandoned over 100 years ago. This review will introduce some of the recent findings that exemplify the roles of breast-tumor-resident microbes in breast carcinogenesis and metastasis and provide mechanistic explanations for these phenomena. Such information would be able to justify the utility of breast-tumor-resident microbes as biomarkers for disease progression and therapeutic targets.

摘要翻译： 

累积证据证实了共生微生物在宿主生理学中的关键作用。尽管自140多年前路易·巴斯德和威廉·拉塞尔时代以来，微生物组一直是主要的研究对象，但近期研究发现某些细胞内细菌在健康与病变组织的病理生理过程中发挥作用，这使微生物组研究进入了新的探索时代。特别是在乳腺癌研究领域，乳腺肿瘤驻留细菌现被视为肿瘤发生和发展过程中的关键参与者。这标志着拉塞尔的细菌致癌理论在沉寂百余年后得以复兴。本综述将介绍近期研究进展，阐释乳腺肿瘤驻留微生物在乳腺癌发生和转移中的作用机制，并为这些现象提供机理解释。这些信息将有助于论证乳腺肿瘤驻留微生物作为疾病进展生物标志物和治疗靶点的应用价值。

原文链接：

Microbiome—Stealth Regulator of Breast Homeostasis and Cancer Metastasis