The impact of racial healthcare disparities has been well documented. Adverse social determinants of health, such as poverty, inadequate housing, and limited access to healthcare, are intricately linked to these disparities and negative health outcomes, highlighting the profound impact that social and economic factors have on individuals’ overall well-being. Recent evidence underscores the role of residential location on individual health outcomes. Despite the importance of a healthy lifestyle, regular physical activity, balanced nutrition, and stress management for favorable health outcomes, individuals living in socioeconomically disadvantaged areas may face obstacles in achieving these practices. Adverse living conditions, environmental factors, and systemic biases against Black Americans perpetuate allostatic load. This, compounded by decreased physical activity and limited healthy food options, may contribute to increased oxidative stress and inflammation, fundamental drivers of morbidities such as cardiovascular disease and cancer. Herein, we perform a narrative review of associations between healthcare disparities, chronic stress, allostatic load, inflammation, and cancer in Black Americans, and we discuss potential mechanisms and solutions. Additional research is warranted in the very important area of cancer disparities.
种族医疗差异的影响已有充分记录。不良的社会健康决定因素，如贫困、住房条件不佳和医疗资源获取受限，与这些差异及不良健康结果密切相关，凸显了社会经济因素对个体整体健康的深远影响。最新证据强调了居住地对个人健康结果的作用。尽管健康生活方式、规律运动、均衡营养和压力管理对良好健康结果至关重要，但居住在社会经济弱势地区的个体在实践这些健康行为时可能面临障碍。不利的生活条件、环境因素以及对非裔美国人的系统性偏见，共同导致了稳态负荷的持续累积。加之体力活动减少和健康食品选择有限，可能进一步加剧氧化应激和炎症反应，而这些正是心血管疾病和癌症等疾病发生发展的根本驱动因素。本文通过叙述性综述，探讨了非裔美国人群体中医疗差异、慢性压力、稳态负荷、炎症与癌症之间的关联，并讨论了潜在机制和解决方案。在癌症差异这一重要领域，仍需开展进一步研究。
肿瘤(癌症)患者之家