Background: This meta-analysis compared the diagnostic performance of [18F] fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) or PET versus Magnetic resonance imaging (MRI) in detecting recurrence or residual tumors at the primary site in patients with nasopharyngeal carcinoma (NPC). Methods: A comprehensive literature search was conducted in the PubMed/MEDLINE and CENTRAL databases to find studies with at least 20 patients with NPC undergoing both [18F]FDG PET/CT (or [18F]FDG PET) and MRI for detecting recurrence or assessing residual disease at the primary site. The pooled sensitivity and specificity of PET/CT and MRI were calculated with 95% confidence intervals (CIs) and compared. Results: Five studies, including 1908 patients (six patient groups), were included. PET imaging had higher sensitivity [93.3% (95% CI: 91.3–94.9%); I2= 52.6%] compared to MRI [80.1% (95% CI: 77.2–82.8%); I2= 68.3%], but the specificity of the two modalities was similar: 93.8% (95% CI: 92.2–95.2%; I2= 0%) for PET/CT and 91.8% (95% CI: 90.1–93.4%; I2= 94.3%) for MRI. The areas under the curve (AUCs) for PET/CT and MRI were 0.978 and 0.924, respectively, without significant difference (p= 0.23). Conclusions: This meta-analysis suggests that [18F]FDG PET imaging and MRI do not significantly differ in diagnostic performance. Nevertheless, [18F]FDG PET imaging shows higher sensitivity than MRI.
背景：本荟萃分析比较了[18F]氟脱氧葡萄糖（[18F]FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）或PET与磁共振成像（MRI）在检测鼻咽癌（NPC）患者原发灶复发或残留肿瘤方面的诊断性能。方法：在PubMed/MEDLINE和CENTRAL数据库中进行全面的文献检索，以寻找至少包含20例鼻咽癌患者同时接受[18F]FDG PET/CT（或[18F]FDG PET）和MRI检测原发灶复发或评估残留病灶的研究。计算并比较PET/CT和MRI的汇总敏感性及特异性，并给出95%置信区间（CIs）。结果：共纳入五项研究，涉及1908例患者（六个患者组）。与MRI相比，PET成像具有更高的敏感性[93.3%（95% CI: 91.3–94.9%）；I²= 52.6%]，而MRI为[80.1%（95% CI: 77.2–82.8%）；I²= 68.3%]，但两种成像方式的特异性相似：PET/CT为93.8%（95% CI: 92.2–95.2%；I²= 0%），MRI为91.8%（95% CI: 90.1–93.4%；I²= 94.3%）。PET/CT和MRI的曲线下面积（AUCs）分别为0.978和0.924，无显著差异（p= 0.23）。结论：本荟萃分析表明，[18F]FDG PET成像与MRI在诊断性能上无显著差异。尽管如此，[18F]FDG PET成像显示出比MRI更高的敏感性。
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