According to the “cancer stem cell” (CSCs) theory, tumors are a diverse and expanding group of malignant cells that originate from a small number of CSCs. Despite treatment, these cells can still become active and proliferate, which can result in distant metastasis and local recurrences. A new paradigm in cancer treatment involves targeting both CSCs and the cancer cells in a tumor. This review aims to examine the literature on methods published to overcome chemoresistance due to the presence of CSCs in head and neck cancers. The review was registered with PROSPERO (ID# CRD42024512809). After Pub Med, Scopus, and WoS database searches, 31 relevant articles on oral squamous cell carcinoma (OSCC) were selected. Compounds that increased chemosensitivity by targeting CSCs in head and neck squamous cell carcinoma (HNSCC) were divided into (1) natural products, (2) adjuvant molecules to traditional chemotherapy, and (3) CSCs targeting patient-specific fresh biopsies for functional precision medicine.
根据“癌症干细胞”（CSCs）理论，肿瘤是由少量CSCs衍生出的一个多样且不断扩增的恶性细胞群体。这些细胞即使在治疗后仍可能被激活并增殖，从而导致远处转移和局部复发。癌症治疗的新范式涉及同时靶向肿瘤中的CSCs和癌细胞。本综述旨在梳理已发表的关于克服头颈癌中因CSCs存在而导致化疗耐药的方法文献。该综述已在PROSPERO注册（ID# CRD42024512809）。通过对PubMed、Scopus和WoS数据库的检索，筛选出31篇关于口腔鳞状细胞癌（OSCC）的相关文献。通过靶向头颈鳞状细胞癌（HNSCC）中的CSCs以增强化疗敏感性的化合物被分为三类：（1）天然产物，（2）传统化疗的辅助分子，以及（3）针对患者特异性新鲜活检样本中CSCs以实现功能精准医疗的靶向策略。
肿瘤(癌症)患者之家