Diagnosing solitary pink skin lesions poses a significant challenge due to the scarcity of specific clinical and dermoscopic criteria. Several benign lesions, such as cherry angioma, clear cell acanthoma, dermal nevus, keloid, hypertrophic scar, and Spitz nevus, often exhibit similar clinical and dermoscopic features. This similarity extends to some malignant lesions, including basal cell carcinoma, actinic keratosis, and amelanotic melanoma, making differentiation difficult. Recent studies highlight the enhanced diagnostic accuracy of reflectance confocal microscopy (RCM), which offers increased sensitivity and specificity compared to dermoscopy alone for diagnosing skin cancer. This study aims to summarize the application of dermoscopy and RCM in distinguishing between benign and malignant pinkish–reddish skin lesions. The integration of RCM with traditional dermoscopic techniques improves the ability to accurately identify and differentiate these lesions. However, it is crucial to note that for any suspicious lesions, a final diagnosis must be confirmed through surgical excision and histopathological evaluation. This comprehensive approach ensures accurate diagnosis and appropriate treatment, highlighting the importance of combining advanced imaging techniques in clinical practice.
孤立性粉色皮肤病变的诊断因缺乏特异性临床及皮肤镜标准而面临显著挑战。多种良性病变如樱桃状血管瘤、透明细胞棘皮瘤、真皮痣、瘢痕疙瘩、增生性瘢痕及Spitz痣,常表现出相似的临床与皮肤镜特征。这种相似性亦延伸至某些恶性病变,包括基底细胞癌、日光性角化病和无色素性黑色素瘤,使得鉴别诊断尤为困难。近期研究凸显反射式共聚焦显微镜(RCM)在皮肤癌诊断中较单纯皮肤镜检查具有更高的敏感性与特异性,显著提升了诊断准确率。本研究旨在总结皮肤镜与RCM在鉴别粉红色至红色皮肤良恶性病变中的应用。RCM与传统皮肤镜技术的结合,增强了准确识别与区分此类病变的能力。然而需重点指出,对于任何可疑病变,最终诊断仍需通过手术切除及组织病理学评估确认。这种综合诊断方法确保了诊断的准确性与治疗的恰当性,凸显了在临床实践中结合先进成像技术的重要性。