Peritoneal carcinomatosis represents an advanced stage of tumors within the peritoneal cavity. Once considered an incurable terminal cancer metastasis, contemporary medicine is on the hunt for certain potentially curative options alongside the present day’s palliative disease management. However, for most patients, peritoneal carcinomatosis continues to pose a fatal late-stage prognosis with a grim future outlook. Over the past two decades, non-coding RNAs have garnered significant attention due to their undeniable significance in regulating cellular processes across all levels. Disruption of the intricate regulation led by non-coding RNAs has been demonstrated to have a substantial impact on various human diseases, particularly in cancer, including solid tumors originating from the organs of the peritoneal cavity. This review aims to offer a comprehensive overview of the current state of knowledge in the under-researched field of peritoneal carcinomatosis, focusing specifically on the role of non-coding RNAs in the development of this condition and delineating potential avenues for future research.
腹膜癌病是腹腔内肿瘤的晚期阶段。曾被视为无法治愈的终末期癌症转移，现代医学在姑息治疗的基础上正积极探索某些潜在根治方案。然而对多数患者而言，腹膜癌病仍预示着致命的晚期预后及严峻的生存前景。过去二十年间，非编码RNA因其在调控各级细胞过程中不可忽视的重要性而备受关注。研究表明，非编码RNA主导的精密调控机制失衡对多种人类疾病——特别是癌症（包括源自腹腔脏器的实体肿瘤）——具有显著影响。本文旨在系统梳理腹膜癌病这一研究不足领域的现有认知，重点阐述非编码RNA在该疾病发生发展中的作用机制，并展望未来可能的研究方向。
Non-Coding RNAs in Peritoneal Carcinomatosis: From Bench to Bedside
肿瘤(癌症)患者之家