Cutaneous squamous cell carcinoma (SCC) is the second most frequent skin cancer, accounting for approximately 20% of all cutaneous malignancies, and with an increasing incidence due to the progressive increment of the average age of life. The diagnosis is usually firstly suspected based on clinical manifestations; however, dermoscopic features may improve diagnostic sensitivity in cases of an uncertain diagnosis and may guide the biopsy, which should be performed to histopathologically prove the tumor. New diagnostic strategies may improve the sensitivity of the cutaneous SCC, such as reflectance confocal microscopy and line-field confocal optical coherence, for which increasing data have been recently published. Imaging has a central role in the staging of the diseases, while its exact role, as well as the choice of the best techniques, during the follow-up are not fully clarified. The aim of this literature review is to describe diagnostic clinical and instrumental tools of cutaneous SCC, with an insight into the role of imaging in the diagnosis and follow-up of cutaneous SCC.
皮肤鳞状细胞癌是第二常见的皮肤恶性肿瘤，约占所有皮肤恶性肿瘤的20%，其发病率随着人口平均寿命的延长而持续上升。该疾病的初步诊断通常基于临床表现，但在诊断不明确时，皮肤镜特征可提高诊断敏感性，并指导活检定位以进行组织病理学确诊。新型诊断策略如反射式共聚焦显微镜和线场共聚焦光学相干断层扫描技术可提升皮肤鳞癌的检测灵敏度，相关研究数据近年持续增加。影像学检查在疾病分期中具有核心地位，但其在随访监测中的确切作用及最佳技术选择尚未完全明确。本文献综述旨在系统阐述皮肤鳞状细胞癌的临床与器械诊断方法，并深入探讨影像学在皮肤鳞癌诊断及随访中的作用。
Cutaneous Squamous Cell Carcinoma: From Diagnosis to Follow-Up
肿瘤(癌症)患者之家