Overall, the past century has seen a substantial decline in gastric cancer, attributable to decreases in risk factors such asH. pyloriinfection, tobacco smoking, and the intake of salt-preserved food. One potential preventive strategy for those at high risk isH. pylorieradication for infected subjects, but confirmation of this effect awaits longer follow-up. Obesity continues to advance and may cause increases in cardia cancer, particularly in Western populations, and careful monitoring of this outcome is warranted in both Western and Asian populations. These changes in gastric cancer epidemiology foreshadow a new era in gastric cancer control and warrant further monitoring of descriptive patterns and risk factors.
总体而言,过去一个世纪胃癌发病率显著下降,这主要归因于幽门螺杆菌感染、吸烟及高盐腌制食品摄入等风险因素的减少。对于高危人群,一种潜在的预防策略是对感染者进行幽门螺杆菌根除治疗,但其效果尚需长期随访验证。肥胖率持续攀升可能导致贲门癌发病率上升,在西方人群中尤为明显,因此有必要在西方及亚洲人群中加强对该趋势的监测。胃癌流行病学的这些变化预示着胃癌防控将进入新阶段,有必要进一步监测其流行特征与风险因素的演变。
Epidemiology of Gastric Cancer—Changing Trends and Global Disparities